Cell-Penetrating Peptide-Conjugated BF -Oxasmaragdyrins as NIRF Imaging and Photothermal Agents.

Cell-penetrating peptides (CPPs) are excellent cell internalizing agents for hydrophobic drug/dye moieties. We exploited this property of CPPs for the cell internalization of BF -oxasmaragdyrin by constructing covalent conjugates of BF -oxasmaragdyrin with CPPs (CRGDK and polyarginine (R )) using a solid-phase peptide synthesis (SPPS) methodology. The CPP-conjugated BF -oxasmaragdyrins were purified by reversed-phase HPLC and characterized by mass spectrometry.

Factors associated with outcomes in organophosphate and carbamate poisoning: a retrospective study.

Organophosphate and carbamate (OPC) poisoning is a major global health hazard requiring immediate medical intervention. Atropine (ATR) is an essential antidote in organophosphate and carbamate poisoning, with the inclusion of cholinesterase reactivators and other anticholinergics, namely pralidoxime (PAM) and glycopyrrolate (GPR). This study aimed to compare the efficacy of various treatment regimens and identify the factors affecting mortality.

Genetic analysis of growth and egg production traits in synthetic colored broiler female line using animal model.

Variance and genetic parameters were estimated for growth and production traits of synthetic broiler female line (PB-2) using REML animal model to delineate the population status, direct additive, maternal genetic, permanent environmental effects, besides genetic trends and performance of economic traits. The overall least squares mean (LSM) for body weights at 0 day (BW0), at 2 weeks (BW2), at 4 weeks (BW4), at 5 weeks (BW5), shank length at 5 weeks (SL5), and breast angle at 5 weeks (BA5) of age were 40.03 g, 207.

Synthesis and Electrochemical Properties of MoS₂/rGO/S Composite as a Cathode Material for Lithium-Sulfur Batteries.

To develop the next-generation energy storage systems, lithium-sulfur batteries represent an attractive option due to its high theoretical capacity, and energy density. In this work, MoS₂/rGO (reduced graphene oxide) was prepared by hydrothermal synthesis and sulfur added by the melt diffusion method. The as-prepared MoS₂/rGO has strong polysulfides entrapping, high conductivity, large surface area, and high catalytic activity, consequently resulting in enhanced rate performance and cycling capability of Li-S batteries.

Hydrothermal Synthesis and Electrochemical Behavior of the SnO₂/rGO as Anode Materials for Lithium-Ion Batteries.

In this work, the hydrothermal method was employed to produce SnO₂/rGO as anode material. Nanostructured SnO₂ was prepared to enhance reversibility and to deal with the undesirable volume changes during cycling. The SnO₂/rGO hybrid exhibits long cycle life in lithium-ion storage capacity and rate capability with an initial discharge capacity of 1327 mAh/g at 0.

Correlation of metabolic syndrome and urolithiasis: A prospective cross-sectional study.

Background: Correlation between urolithiasis and metabolic syndrome has been demonstrated in the literature. This study assessed the association of metabolic syndrome and its components with urolithiasis in Indian patients.

Methods: A cross-sectional prospective observation study included patients aged >18 years with urolithiasis.

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.

Background: Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder. Notwithstanding the extensive studies using rodent and other pre-clinical models of FXS, which have provided detailed mechanistic insights into the pathophysiology of this disorder, it is only relatively recently that human stem cell-derived neurons have been employed as a model system to further our understanding of the pathophysiological events that may underlie FXS. Our study assesses the physiological properties of human pluripotent stem cell-derived cortical neurons lacking fragile X mental retardation protein (FMRP).

Combined cardiac anomalies in Noonan syndrome: A case report.

Introduction: Noonan syndrome is the second most common syndromic cause of congenital heart disease. Most patients have an autosomal dominant inheritance, but some cases may be sporadic. Pulmonary stenosis is the most common cardiac manifestation in Noonan syndrome, associated with the atrial septal defect and hypertrophic cardiomyopathy.

Assessment of dental satisfaction among school teachers in a metropolitan city.

Background And Aims: Dental satisfaction is a multi-dimensional concept, reflecting the total experience of health care and a major driving force of treatment seeking behaviour. At community level, school teachers, being the role model, also play a major role in public health. The aim of this study is to assess the dental satisfaction among school teachers in Hyderabad.

Enhanced Algal Photosynthetic Photon Efficiency by Pulsed Light.

We present experimental results demonstrating that, relative to continuous illumination, an increase of a factor of 3-10 in the photon efficiency of algal photosynthesis is attainable via the judicious application of pulsed light for light intensities of practical interest (e.g., average-to-peak solar irradiance).

A rare case of sarcoidosis causing granulomatous interstitial nephritis presenting as non oliguric acute renal failure in the Indian subcontinent.

Sarcoidosis is a systemic disease characterized by non caseating granulomatous inflammation. Sarcoidosis can affect any organ, but it most commonly involves the lungs and lymph nodes. The exact incidence of renal involvement in sarcoidosis remains unclear, but it is found to be rare.

Assessment of cognitive impairment and its correlation with vitamin D levels patients on maintenance hemodialysis.

Cognitive impairment (CI) is common in patients with chronic kidney disease, and its prevalence increases in patients on hemodialysis (HD). Different factors were identified to be the cause of cognitive dysfunction, of which Vitamin D, which is known to have pleiotropic effects, has been implicated for the neurocognitive decline of functions. We assessed the prevalence of cognitive dysfunction in patients on HD in our center and also studied the deficiency of Vitamin D on CI.

N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells.

The ribosomal p70 S6 Kinase 1 (S6K1) has been implicated in the etiology of complex neurological diseases including autism, depression and dementia. Though no major gene disruption has been reported in humans in RPS6KB1, single nucleotide variants (SNVs) causing missense mutations have been identified, which have not been assessed for their impact on protein function. These S6K1 mutations have the potential to influence disease progression and treatment response.

Difluoroacetaldehyde N-Triftosylhydrazone (DFHZ-Tfs) as a Bench-Stable Crystalline Diazo Surrogate for Diazoacetaldehyde and Difluorodiazoethane.

Despite the growing importance of volatile functionalized diazoalkanes in organic synthesis, their safe generation and utilization remain a formidable challenge because of their difficult handling along with storage and security issues. In this study, we developed a bench-stable difluoroacetaldehyde N-triftosylhydrazone (DFHZ-Tfs) as an operationally safe diazo surrogate that can release in situ two low-molecular-weight diazoalkanes, diazoacetaldehyde (CHOCHN ) or difluorodiazoethane (CF HCHN ), in a controlled fashion under specific conditions. DFHZ-Tfs has been successfully employed in the Fe-catalyzed cyclopropanation and Doyle-Kirmse reactions, thus highlighting the synthetic utility of DFHZ-Tfs in the efficient construction of molecule frameworks containing CHO or CF H groups.

Categorization & Recognition of Lung Tumor Using Machine Learning Representations.

Background: Lung Cancer is the disease spreading around the world nowadays. Early recognition of lung disease is a difficult task as the cells which cause tumor will grow quickly and the majority of these cells are enclosed with each other. From the beginning of the treatment, tumor detection handling systems which are generally utilized for the diagnosis of lung cancer, recognizable proof of hereditary and ecological elements is imperative in creating a novel technique for lung tumor detection.

Practice Guidelines for Enteral Nutrition Management in Dysglycemic Critically Ill Patients: A Relook for Indian Scenario.

Background And Aim: Intensive-care practices and settings differ for India in comparison to other countries. While guidelines are available to direct the use of enteral nutrition (EN), there are no recommendations specific to nutritional management of EN in dysglycemic patients, specific to patients in Indian critical care settings. Advisory board meetings were arranged to develop the practice guidelines specific to the Indian context, for the use of EN in dysglycemic critically ill patients and to overcome challenges in this field.

Measurements and Monte Carlo calculation of radial dose and anisotropy functions of BEBIG Co high-dose-rate brachytherapy source in a bounded water phantom.

Purpose: The study compared the experimentally measured radial dose function, g(), and anisotropy function, (,θ), of a BEBIG Co (Co0.A86) high-dose-rate (HDR) source in an in-house designed water phantom with egs_brachy Monte Carlo (MC) calculated values. MC results available in the literature were only for unbounded phantoms, and there are no currently published data in the literature for experimental data compared to MC calculations for a bounded phantom.

Smoking and alcoholism among adult population and its association with outlet density in a hilly area of North India.

Background: The rising burden of non-communicable diseases is a threat to India. The behavioural risk factors having largest contribution to NCDs. Neighbourhood retailing of tobacco products, and alcohol are important risk factors.

Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation.

The proteasome inhibitor bortezomib is the most successfully applied chemotherapeutic drug for treating multiple myeloma. However, its clinical efficacy reduced due to resistance development. The underlying molecular mechanisms of bortezomib resistance are poorly understood.

Transesophageal echocardiographic evaluation of pulmonary vein diastolic wave deceleration time - As a predictor of left atrial pressure.

Background: The deceleration time of the pulmonary venous diastolic flow has been well-correlated with invasive pulmonary capillary wedge pressure in several studies regardless of left ventricular systolic function. This study was conducted to correlate deceleration time of pulmonary venous diastolic wave, DT, and left atrial pressure (LAP), obtained noninvasively from mitral early diastolic inflow velocity-to-early diastolic mitral annulus velocity ratio (E/e'), and to assess the ease of each method in patients with coronary artery disease undergoing off-pump coronary artery bypass grafting (OPCAB) by transesophageal echocardiography.

Methods: Forty-five adult patients with coronary artery disease, with left ventricular ejection fraction of ≥50% posted for elective OPCAB were enrolled in the study.

Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS.

Prokaryotic mechanosensitive (MS) channels open by sensing the physical state of the membrane. As such, lipid-protein interactions represent the defining molecular process underlying mechanotransduction. Here, we describe cryo-electron microscopy (cryo-EM) structures of the small-conductance mechanosensitive channel (MscS) in nanodiscs (ND).

Synthetic Semimetals with van der Waals Interfaces.

The assembly of suitably designed van der Waals (vdW) heterostructures represents a new approach to produce artificial systems with engineered electronic properties. Here, we apply this strategy to realize synthetic semimetals based on vdW interfaces formed by two different semiconductors. Guided by existing ab initio calculations, we select WSe and SnSe mono- and multilayers to assemble vdW interfaces and demonstrate the occurrence of semimetallicity by means of different transport experiments.

Data on application of water quality index method for appraisal of water quality in around cement industrial corridor, Yerraguntla Mandal, Y.S.R District, A.P South India.

The present paper aims at determining the status and trends of groundwater quality by applying water quality index method from 22 villages around Cement industries, Yerraguntla Mandal, Y.S.R District, A.