Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties.

In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines based on 4-(N,N-dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The structure of all synthesized compounds were confirmed by spectral date (FT-IR, H NMR, C NMR) and elemental analysis. We evaluated the anticancer activity of these compounds toward two cell lines: A459 cell line (lung cancer cells) and MCF7 cell line (breast cancer cells).

Solid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations.

Heterocyclic compounds with effective solid-state luminescence offer a wide range of uses. It has been observed that combining pyrimidine and indole moieties in a single molecule can enhance material behavior dramatically. Here, different heterocyclic compounds with indole and pyrimidine moieties have been synthesized effectively, and their structures have been validated using NMR, IR, and mass spectroscopy.

Cadmium oxide nanoparticles/graphene composite: synthesis, theoretical insights into reactivity and adsorption study.

Graphene-based metal oxide nanocomposites are interesting and promising kinds of nanocomposites due to their large specific area, fast kinetics, and specific affinity towards heavy metal contaminants. In this work, a facile and cost-effective route was used to synthesize CdO nanoparticles (CdO NPs) and graphene-based CdO nanocomposite (G-CdO). The prepared nanomaterials were characterized and explored for lead removal from water.

Nitrophenyl-Group-Containing Heterocycles. I. Synthesis, Characterization, Crystal Structure, Anticancer Activity, and Antioxidant Properties of Some New 5,6,7,8-Tetrahydroisoquinolines Bearing 3(4)-Nitrophenyl Group.

Regioselective cyclocondensation of 2,4-diacetyl-5-hydroxy-5-methyl-3-(3-nitrophenyl/4-nitrophenyl)cyclohexanones , with cyanothioacetamide afforded the corresponding 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-(3- and -4-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2)-thiones ,. Reaction of compounds , with ethyl iodide, 2-chloroacetamide (), or its -aryl derivatives - in the presence of sodium acetate trihydrate gave 3-ethylthio-5,6,7,8-tetrahydroisoquinoline and (5,6,7,8-tetrahydroisoquinolin-3-ylthio)acetamides -, respectively. Cyclization of compounds -,, into their isomeric 1-amino-6,7,8,9-tetrahydrothieno[2,3-]isoquinoline-2-carboxamides -,, was achieved by heating in ethanol containing a catalytic amount of sodium carbonate.

Effect of photovoltaics shading on the growth of chili pepper in controlled greenhouses.

The integration of photovoltaic into a greenhouse has been implemented to maximize the energy output and crop production yield from the same land space. The effect of greenhouse external shading of opaque crystalline silicon photovoltaic (PV) panels at 13-26% of the roof area on the microclimate and growth of Chili pepper was investigated. The PV panels were divided into two arrays (each of 4 PVs) and fixed separately on two external pillars of 4 m height in the Southeast and Northwest directions, respectively.

Crystal structure and Hirshfeld surface analysis of 2-{[7-acetyl-4-cyano-6-hy-droxy-8-(4-meth-oxy-phen-yl)-1,6-dimethyl-5,6,7,8-tetra-hydro-iso-quino-lin-3-yl]sulfan-yl}--phenyl-acetamide.

The title mol-ecule, CHNOS, adopts a conformation with the two phenyl substituents disposed on opposite sides of the mean plane of the iso-quinoline unit. In the crystal, corrugated layers of mol-ecules are formed by N-H⋯O, C-H⋯N and C-H⋯S hydrogen bonds together with C-H⋯π(ring) inter-actions. These layers are connected by C-H⋯O contacts.

Synthesis of Novel Biocompatible Thienopyrimidine Chromophores with Aggregation-Induced Emission Sensitive to Molecular Aggregation.

Biocompatible luminogens with aggregation-induced emission (AIE) have several applications in the biology field, such as in detecting biomacromolecules bioprobes and in bio-imaging. Due to their bioactivities and light-emitting properties, many heterocyclic compounds are good candidates for such applications. However, heterocyclic π-conjugated systems with AIE behavior remain rare as strong intermolecular π-π interactions usually quench their emission.

Green-synthesized copper nano-adsorbent for the removal of pharmaceutical pollutants from real wastewater samples.

The release of Non-Steroidal Anti-Inflammatory drugs (NSAIDs) such as Ibuprofen (Ibu), Naproxen (Nab) and Diclofenac (Dic) to the aquatic system cause serious environmental problems. In this study, green-synthesized copper nanoparticles (Cu NPs) have been used as nano-adsorbent for the removal of Ibu, Nab, and Dic from wastewater samples. Formation of Cu NPs was confirmed by different analytical techniques.

Design, Synthesis, Characterization, and Insecticidal Bioefficacy Screening of Some New Pyridine Derivatives.

A lot of insecticides are found nowadays, but neonicotinoids are considered the most famous. So, a series of pyridine derivatives neonicotinoids analogues, namely, 3-cyano-4,6-dimethylpyridine-2(1)-one (), 2-chloro-3-cyano-4,6-dimethylpyridine (), 3-cyano-4,6-dimethylpyridine-2(1)-thione (), 3-cyano-4,6-distyrylpyridine-2(1)-thione (), 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)--phenylacetamide (), 3-amino--phenyl-4,6-distyrylthieno[2,3-]pyridine-2-carboxamide (), 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)--(-tolyl)acetamide (), 3-amino-4,6-distyryl--(-tolyl)thieno[2,3-]pyridine-2-carboxamide (), 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)--(4-methoxyphenyl)acetamide (), and 3-amino--(4-methoxyphenyl)-4,6-distyrylthieno[2,3-]pyridine-2-carboxamide (), have been designed and synthesized in pure state, and their agricultural bioefficacy as insecticides against cowpea aphid Koch was screened. The structures of the synthesized compounds were verified by means of spectroscopic and elemental analyses.

Chemical design and toxicity evaluation of new pyrimidothienotetrahydroisoquinolines as potential insecticidal agents.

Neonicotinoids are the most widely used from all existing pesticides. So, in purpose to discover new pesticides being more effective against the aphid, twelve heterocyclic compounds neonicotinoid analogs have been prepared in a pure state; pyrimidothienotetrahydroisoquinolines and their toxicity as potential insecticidal agents against cowpea Aphid, Koch was screened. Their characterizations by using spectroscopic analyses were performed.

Biosynthesis of copper nanoparticles using aqueous extract: antimicrobial and anticancer activities.

A cost-effective method for the biosynthesis of copper nanoparticles (Cu-NPLs) using extract under optimum conditions has been presented. The use of extracts for the synthesis of Cu-NPLs has been investigated for the first time. The Cu-NPLs are stable due to bio-capping by the extract residues.

Metal-conductive polymer hybrid nanostructures: preparation and electrical properties of palladium-polyimidazole nanowires.

A simple, convenient method for the formation of hybrid metal/conductive polymer nanostructures is described. Polyimidazole (PIm) has been templated on λ-DNA via oxidative polymerisation of imidazole using FeCl3 to produce conductive PIm/DNA nanowires. The PIm/DNA nanowires were decorated with Pd (Pd/PIm/DNA) by electroless reduction of PdCl4(-2) with NaBH4 in the presence of PIm/DNA; the choice of imidazole was motivated by the potential Pd(II) binding site at the pyridinic N atom.

Networks of DNA-templated palladium nanowires: structural and electrical characterisation and their use as hydrogen gas sensors.

Electroless templating on DNA is established as a means to prepare high aspect ratio nanowires via aqueous reactions at room temperature. In this report we show how Pd nanowires with extremely small grain sizes (< 2 nm) can be prepared by reduction of PdCl4(2-) in the presence of lambda-DNA. In AFM images the wires are smooth and uniform in appearance, but the grain size estimated by the Scherrer treatment of line broadening in X-ray diffraction is less than the diameter of the wires from AFM (of order 10 nm).

Smooth and conductive DNA-templated Cu₂O nanowires: growth morphology, spectroscopic and electrical characterization.

DNA strands have been used as templates for the self-assembly of smooth and conductive cuprous oxide (Cu₂O) nanowires of diameter 12-23 nm and whose length is determined by the template (16 μm for λ-DNA). A combination of spectroscopic, diffraction and probe microscopy techniques showed that these nanowires comprise single crystallites of Cu₂O bound to the DNA molecules which fused together over time in a process analogous to Ostwald ripening, but driven by the free energy of interaction with the template as well as the surface tension. Electrical characterization of the nanowires by a non-contact method, scanned conductance microscopy and by contact mode conductive AFM showed the wires are electrically conductive.

Preparation and characterization of conductive and photoluminescent DNA-templated polyindole nanowires.

Polyindole (PIn) nanowires were formed on a lambda-DNA template by chemical oxidation of indole using aqueous FeCl3. The resulting nanowires are smooth, regular, conductive and had diameters in the range of 5-30 nm. These features allow them to be aligned by molecular combing and studied by scanned conductance microscopy, conductive AFM, and two-terminal I-V measurements.