Management of isolated native tricuspid valve infective endocarditis by a multidisciplinary program: a single-center retrospective cohort study.

Background: Isolated native tricuspid valve infective endocarditis remains a challenging disease to treat given the large number of patients with substance use disorder. There is limited data on the optimal treatment strategy and the impact of a multidisciplinary endocarditis program on outcomes for this population.

Objectives: To assess the clinical outcomes associated with management of native tricuspid valve infective endocarditis by a multidisciplinary team.

Probing the Linear-to-Plastic Transition in Polymer Nanocomposites via Atomistic Simulations: The Role of Interphases.

Polymer nanocomposites have found ubiquitous use across diverse industries, attributable to their distinctive properties and enhanced mechanical performance compared to conventional materials. Elucidating the elastic-to-plastic transition in polymer nanocomposites under diverse mechanical loads is paramount for the bespoke design of materials with desired mechanical attributes. In the current work, the elastic-to-plastic transition is probed in model systems of polyethylene oxide (PEO) and silica, SiO, nanoparticles, through detailed atomistic molecular dynamics simulations.

Unraveling the Effect of Strain Rate and Temperature on the Heterogeneous Mechanical Behavior of Polymer Nanocomposites via Atomistic Simulations and Continuum Models.

Polymer nanocomposites are characterized by heterogeneous mechanical behavior and performance, which is mainly controlled by the interaction between the nanofiller and the polymer matrix. Optimizing their material performance in engineering applications requires understanding how both the temperature and strain rate of the applied deformation affect mechanical properties. This work investigates the effect of strain rate and temperature on the mechanical properties of poly(ethylene oxide)/silica (PEO/SiO) nanocomposites, revealing their behavior in both the melt and glassy states, via atomistic molecular dynamics simulations and continuum models.

Symmetric leukoencephalopathy associated with systemic lupus erythematosus: A systematic review of a distinctive neurorheumatologic syndrome.

Background: A symmetric leukoencephalopathy can occur in the context of systemic lupus erythematosus (SLE), often as a first manifestation of underlying rheumatologic disease. Recognition of this distinctive syndrome can prompt investigation for SLE when undiagnosed, or prompt treatment initiation when the diagnosis is already known. Earlier recognition of this syndrome could lead to more effective treatment of the disease.

Distribution of Mechanical Properties in Poly(ethylene oxide)/silica Nanocomposites via Atomistic Simulations: From the Glassy to the Liquid State.

Polymer nanocomposites exhibit a heterogeneous mechanical behavior that is strongly dependent on the interaction between the polymer matrix and the nanofiller. Here, we provide a detailed investigation of the mechanical response of model polymer nanocomposites under deformation, across a range of temperatures, from the glassy regime to the liquid one, via atomistic molecular dynamics simulations. We study the poly(ethylene oxide) matrix with silica nanoparticles (PEO/SiO) as a model polymer nanocomposite system with attractive polymer/nanofiller interactions.

Comparison of Medical Therapy, Valve Surgery, and Percutaneous Mechanical Aspiration for Tricuspid Valve Infective Endocarditis.

Background: The opioid pandemic, and particularly injection drug use, has led to an increase in cases of tricuspid valve infective endocarditis. Indications for valve surgery in right-sided infective endocarditis are not well-defined. Percutaneous mechanical aspiration is considered an alternative in patients at high risk for re-infection of a prosthetic valve but lacks robust outcomes data.

Description and taxonomic assessment of fossil Cercopithecidae from the Pliocene Galili Formation (Ethiopia).

The Mount Galili Formation in the Afar region, Ethiopia, samples a critical time in hominin evolution, 4.4 to 3.8 Ma, documenting the last appearance of Ardipithecus and the origin of Australopithecus.

Invasive Infection in Patients With Bacterial Infective Endocarditis.

Over 21 months, 12 patients with invasive infections detected during the course of treatment of bacterial endocarditis, including 11 with candidemia, were identified. Invasive infections can occur as a complication of bacterial endocarditis and may occur more frequently in patients with injection drug use and broad-spectrum antibiotic exposure.

Shared Decision-Making for Partial Oral Antibiotic Treatment of Infective Endocarditis: A Case Series.

Although literature has demonstrated the noninferiority of oral antibiotics in the treatment of infectious endocarditis, widespread adoption of this practice has yet to occur in the United States. We report on 32 patients with infectious endocarditis treated by a multidisciplinary endocarditis team and a standardized approach to partial oral antibiotic therapy with a high rate of clinical success.

Severe Symptomatic Aortic Stenosis in an Octogenarian with Congenitally Corrected Transposition of the Great Arteries.

• ccTGA accounts for 0.5%-1.4% of patients with congenital heart disease.

Beyond a team: The comprehensive interdisciplinary endocarditis program in the United States.

Although multidisciplinary teams have been shown to decrease in-hospital mortality for patient with infectious endocarditis, most studies have focused on the inpatient role of these teams, and are primarily based at European tertiary care centers. There is limited literature available on the optimal longitudinal care of this patient population. Here we outline our experience developing an interdisciplinary endocarditis program at the University of Kentucky, which cares for patients from their index hospitalization into the outpatient setting, while also coordinating transfers from regional hospitals and offering education to regional providers.

Revealing the Role of Chain Conformations on the Origin of the Mechanical Reinforcement in Glassy Polymer Nanocomposites.

Understanding the mechanism of mechanical reinforcement in glassy polymer nanocomposites is of paramount importance for their tailored design. Here, we present a detailed investigation, via atomistic simulation, of the coupling between density, structure, and conformations of polymer chains with respect to their role in mechanical reinforcement. Probing the properties at the molecular level reveals that the effective mass density as well as the rigidity of the matrix region changes with filler volume fraction, while that of the interphase remains constant.

Small fiber neuropathy associated with ANCA positivity: a case series and brief literature review.

Introduction: Small fiber neuropathy [SFN] is a common peripheral neurologic disorder with a vast array of implicated etiologies. It has previously been proposed that some forms of immune-mediated small fiber neuropathy are driven by vasculitis, though antinuclear cytoplasmic antibodies [ANCA] antibodies have not commonly been reported in association with SFN, thus far. We present this case series to discuss the observation of a possible novel association between ANCA and SFN.

Neurologic Complications of Endocrine Disorders.

Objective: This article provides an overview of the neurologic complications of the most prevalent endocrine disorders in adults with an emphasis on relevant neurologic symptoms, signs, and laboratory and neuroimaging findings.

Latest Developments: Although the mechanisms of many of the neurologic complications discussed here remain unclear, our understanding of the impacts of diabetes and hypothyroidism on the nervous system and muscle, including complications of rapid correction of chronic hyperglycemia, has advanced in recent years. Recent large studies have not demonstrated a convincing association between subclinical or overt hypothyroidism and cognitive decline.

Multimodal Imaging and Management of a Metastatic Cardiac Intimal Sarcoma.

• Echocardiography is the modality of choice for initial cardiac tumor diagnosis. • CMR aids in tissue characterization, perfusion assessment, and delineating anatomy. • Intimal sarcomas are the most common primary cardiac sarcomas.

A methodology for determining the local mechanical properties of model atomistic glassy polymeric nanostructured materials.

We propose a methodology for calculating the distribution of the mechanical properties in model atomistic polymer-based nanostructured systems. The use of atomistic simulations is key in unravelling the fundamental mechanical behavior of composite materials. Most simulations involving the mechanical properties of polymer nanocomposites (PNCs) concern their global (average) properties, which are typically extracted by applying macroscopic strain on the boundaries of the simulation box and calculating the total (global) stress by invoking the Virial formalism over all atoms within the simulation box; thus, extracting the pertinent mechanical properties from the corresponding stress-strain relation.

Biochronology of South African hominin-bearing sites: A reassessment using cercopithecid primates.

Despite recent advances in chronometric techniques (e.g., Uranium-Lead [U-Pb], cosmogenic nuclides, electron spin resonance spectroscopy [ESR]), considerable uncertainty remains regarding the age of many Plio-Pleistocene hominin sites, including several in South Africa.

Mechanical Behavior of Polymer Nanocomposites via Atomistic Simulations: Conformational Heterogeneity and the Role of Strain Rate.

Polymer nanohybrids with a high fraction of nanofillers have been found to exhibit improved mechanical properties compared to the neat polymer homogeneous systems. Since polymer-based materials are characterized by a broad range of relaxation times, it is expected that their response under external load would depend on the actual rate of the applied deformation. In this work, we investigate the heterogeneous mechanical behavior in glassy poly(ethylene oxide)/silica nanoparticles (PEO/SiO) nanocomposites via detailed atomistic molecular dynamics simulations.

Baseline malaria prevalence at the targeted pre-elimination districts in Ethiopia.

Background: Encouraged by the previous success in malaria control and prevention strategies, the Ethiopian ministry of health launched malaria elimination with a stepwise approach by primarily targeting the low-transmission Districts and their adjacent areas/zones in order to shrink the country's malaria map progressively. Hence, this community survey was conducted to establish baseline malaria information at the preliminary phase of elimination at targeted settings.

Methods: A community-based cross-sectional survey was conducted at 20 malaria-elimination targeted Districts selected from five Regional states and one city administration in Ethiopia.

Influence of fermentation time on proximate composition and microbial loads of Enset, (), sampled from two different agroecological districts.

In southern Ethiopian households, kocho is one of the staple foods which can be kept longer and fermented naturally using locally prepared pits, but evidence about the influences of fermentation of kocho at a different time and agroecology on proximate compositions and microbial loads are limited. Fermented kocho samples at different fermentation times were collected from highland and midland districts of Sidama region of Ethiopia. The standard procedure of AOAC (2005) method was followed.

Vulnerability and Impact Analysis of the IEC 61850 GOOSE Protocol in the Smart Grid.

IEC 61850 is one of the most prominent communication standards adopted by the smart grid community due to its high scalability, multi-vendor interoperability, and support for several input/output devices. Generic Object-Oriented Substation Events (GOOSE), which is a widely used communication protocol defined in IEC 61850, provides reliable and fast transmission of events for the electrical substation system. This paper investigates the security vulnerabilities of this protocol and analyzes the potential impact on the smart grid by rigorously analyzing the security of the GOOSE protocol using an automated process and identifying vulnerabilities in the context of smart grid communication.