Porphyromonas gingivalis enhances the senescence-induced increase of 5-alpha reductase in gingival fibroblasts.

Objectives: Aging is characterized by chronic inflammatory activity. Senescent cells increase with chronic inflammation and age-related pathologies, including periodontal disease. As a critical regulator of tissue inflammaging, we hypothesized that 5α reductase (5αR) is associated with periodontal disease and bacteria-induced senescence in gingival fibroblasts.

Association between androgenetic alopecia and periodontitis.

Aim: Androgenic alopecia (AGA) is men's most common form of hair loss. It is affected by changes in the expression and activity of 5αR and the metabolism of testosterone and DHT. There is an association between AGA and systemic inflammatory diseases.

The Evaluation of Different Polishing Techniques' Effects on the Post-operative External Staining of Enamel in Primary and Permanent Tooth.

Objective This study aimed to examine patient complaints on recoloration development after polishing applications in primary and permanent teeth that differed in enamel composition and to determine the ideal polishing method. Methods A total of 30 permanent upper incisors and 30 primary molars were randomly divided into three groups of 10 using three different polishing techniques. Each polishing method (rubber, brush, and air polishing) was applied to the test surface of its own group.

Effect of low-level laser on guided tissue regeneration performed with equine bone and membrane in the treatment of intrabony defects: a clinical study.

Objective: The purpose of the present study was to evaluate the clinical results of guided tissue regeneration (GTR) after the application of equine bone and membrane alone or combined with low-level laser therapy (LLLT) for the treatment of periodontal defects.

Materials And Methods: This study was an intra-individual longitudinal study of 6 months' duration conducted using a split-mouth and randomized design. In 13 periodontitis patients with bilateral intrabony periodontal defects, while one defect site was treated with GTR plus LLLT (1064 nm, 100 mW, with energy density of 4 J/cm(2)), the contralateral defect site was treated with guided GTR alone.

Clinical effects of Nd:YAG laser applications during nonsurgical periodontal treatment in smoking and nonsmoking patients with chronic periodontitis.

Objective: The purpose of this study was to compare the clinical efficacy of nonsurgical periodontal treatment with and without Nd:YAG laser (NDL) applications in smoking and nonsmoking patients with moderate chronic periodontitis (CP).

Materials And Methods: The study population consisted of 52 patients with generalized moderate CP. The study compared the clinical effects of scaling and root planing (SRP) and SRP plus NDL in periodontal pockets measuring between 4 and 6 mm of smoking and nonsmoking patients with CP.

Effect of 1,064-nm Nd:YAG laser therapy on GCF IL-1β and MMP-8 levels in patients with chronic periodontitis.

The aim of this study was to evaluate the long-term effects of a combined periodontal treatment of scaling and root planing (SRP) and Nd:YAG laser (NDL) in chronic periodontitis (CP) patients. This was accomplished by determining the periodontal indices and the interleukin-1beta (IL-1β) and matrix metalloproteinase-8 (MMP-8) levels of the gingival crevicular fluid (GCF). This study was performed according to a random split-mouth-design, controlled clinical trial for sulcular debridement on 40 teeth from 20 patients with generalized moderate chronic periodontitis.

Evaluation of pain levels after Nd: YAG laser and scalpel incisions: an experimental study in rats.

Background: Postoperative pain is a recognized sequel of periodontal surgery. The pain experience has been shown to peak in the first 24 hours following the procedure, and to decrease rapidly in subsequent days. The aim of the present study was to evaluate the pain levels following scalpel- and laser-incision of rat hind paws.

Association between TNF-alpha, TGF-beta1, IL-10, IL-6 and IFN-gamma gene polymorphisms and generalized aggressive periodontitis.

Objective: The aim of this study was to investigate links among cytokine genetic variants and generalized aggressive periodontitis (GAgP).

Methods: Thirty-five patients with generalized aggressive periodontitis and 85 healthy controls without periodontitis were included in the study. Probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI) were recorded as clinical parameters.

Genetic variation of myeloperoxidase gene contributes to aggressive periodontitis: a preliminary association study in Turkish population.

Myeloperoxidase (MPO) is a lysosomal enzyme found in the azurophilic granules of polymorphonuclear leukocytes. It is involved in the defense against periodontal bacteria, and is also able to mediate inflammatory tissue destruction in aggressive and chronic periodontitis. The aim of this study was to explore the association between MPO-463G/A gene polymorphism and aggressive periodontitis (AgP) and chronic periodontitis (CP).

Comparative evaluation of Nd:YAG laser and fluoride varnish for the treatment of dentinal hypersensitivity.

Introduction: Various methods and materials are used in the treatment of dentin hypersensitivity. The aim of this randomized prospective controlled clinical trial was to evaluate and compare the desensitizing effects of the neodymium-doped yttrium aluminium garnet (Nd:YAG) laser and fluoride varnish by considering the degree of pre- and posttreatment pain, discomfort, and functional complications.

Methods: Twenty patients with clinically diagnosed cervical dentin hypersensitive teeth were included and randomly allocated to either the application of fluoride varnish (group fluoride) or Nd:YAG laser (100 mJ, 20 Hz; group Nd:YAG).

Effects of different blood groups on the reproduction of periodontal pocket bacteria.

Background: Many studies have been conducted proving the relation between different blood groups and certain diseases. It was claimed in these studies that H pylori showed different distribution according to different blood groups. In dentistry, the relation between blood groups and dental diseases was investigated in a limited number of studies and it was concluded that there might be a relation between them.

In vivo assessment of zinc deficiency on craniofacial growth in a rat model.

Objectives: The aim of this study was to investigate the effects of low levels of zinc intake on the rat mandible and maxilla during growth and to compare these results with those of zinc-containing rats.

Methods: The study was carried out on 14 Sprague-Dawley rats. The rats were randomly divided into two groups.

An evaluation of different treatments for recurrent aphthous stomatitis and patient perceptions: Nd:YAG laser versus medication.

Objective: The aim of this randomized controlled clinical trial was to determine the anxiety levels of patients with recurrent aphthous stomatitis (RAS) prior to therapy with the Nd:YAG laser or medication, and to compare the effects of these different treatment methods on the degree of post-treatment pain, discomfort, and functional complications (eating and speech) experienced.

Materials And Methods: Twenty patients with RAS-related oral problems were included in the study. Levels of pre- and post-treatment pain and functional complications were assessed at patient visits on days 1, 4, and 7.

Effect of Nd: YAG laser irradiation on the treatment of oral malodour associated with chronic periodontitis.

Aim: To investigate, using a randomised-controlled, single clinical trial whether treating periodontitis with non-surgical periodontal treatment procedures and laser applications can decrease the effect of oral malodour and compare the effectiveness of the different therapies.

Methods: Sixty patients suffering from chronic periodontitis and complaining of oral malodour were included in the study. The parameters measured included organoleptic scoring, volatile sulphur compound (VSC) levels, gingival index, plaque index, probing depth and clinical attachment levels before and after the different treatment procedures (oral hygiene instructions, scaling-root planing-SRP and subgingival Nd: YAG laser irradiation).

The influence of type-1 diabetes mellitus on dentition and oral health in children and adolescents.

Purpose: The present study is to investigate the effects of type 1 diabetes mellitus on dentition and oral health for children and adolescents.

Materials And Methods: The investigation was carried out on 100 subjects. The first group consisted of 50 subjects with type 1 diabetes mellitus (21 females, 29 males), age 9+/-0.

The changes in the T-lymphocyte subsets in a population of Turkish children with puberty gingivitis.

Objective: The aim of the study was to investigate the number of CD4 and CD8 T lymphocytes, analyse subjects with gingivitis and those without, and determine the role of T lymphocytes in the pathobiology of puberty gingivitis.

Material And Methods: Fifty individuals with and without puberty gingivitis were recruited for this study. The CD4(+) and CD8(+) T-lymphocyte counts were determined using flow cytometry on the biopsy samples, and the CD4(+)/CD8(+) ratio was calculated.

The Effect of ABO Blood Types on Periodontal Status.

Objectives: The purpose of the present study was to determine whether there was a relationship between periodontal diseases and ABO blood groups.

Methods: This epidemiological study was carried out on 1351 subjects who were randomly selected from individuals referred to the Faculty of Dentistry clinics for periodontal treatment or for other reasons regarding dental health. The study based on periodontal condition, blood group, and medical history.

The relationship between teething and handedness.

The aim of this study was to evaluate the role of tooth eruption sequences as an indicator of handedness. The investigation was carried out on 92 healthy children. The questionnaire form was filled out for each child.

New evidence of premature oxidative DNA damage: mitochondrial DNA deletion in gingival tissue of patients with periodontitis.

Background: Overproduction of reactive oxygen species (ROS) causes increased oxidative stress in gingival tissue. It has been generally accepted that increased oxidative stress might contribute to additional damage of lipids, proteins, and DNA molecules. The mitochondrial DNA (mtDNA) mutation is a superb biomarker of oxidative damage.

The changes in T lymphocyte subsets following periodontal treatment in patients with chronic periodontitis.

Objective: The aim of this study was to determine whether there was any change in T-lymphocyte subsets in patients with chronic periodontitis after applying different periodontal treatment methods.

Patients And Methods: Twenty-four patients with chronic periodontitis were included in the study. In every phase of the treatment (pretreatment, initial treatment, curettage and flap operations) the biopsy samples were taken from the gingival tissues at sites of chronic periodontitis.

Differences in dental and bone maturation in regions with or without hemihypertrophy in two patients with Russell-Silver syndrome.

Hemihypertrophy (hemihyperplasia) is defined as asymmetric body overgrowth of one or more body parts. Hemihypertrophy can be isolated or be part of well-defined syndromes, such as Russell-Silver syndrome (RSS). RSS is characterized by severe intrauterine growth retardation, postnatal short stature, asymmetry of the face, body, and limbs, short and incurved fifth fingers, broad forehead, pointed small triangular shaped face, girdle nose, normal psychomotor development, variations in the pattern of sexual development, and dental and oral abnormalities.

The gingival crevicular fluid ciprofloxacin level in subjects with gingivitis and periodontitis, and its effects on clinical parameters.

Objectives: The purpose of this study, conducted on patients with gingivitis and periodontitis, was twofold: to find out the serum and gingival crevicular fluid concentration of ciprofloxacin, which is a common drug used effectively against Actinobacillus actinomycetemcomitans and to determine the effects of ciprofloxacin administration on clinical parameters.

Method: A total of 32 adult patients, consisting of 16 subjects with gingivitis and 16 subjects with untreated chronic periodontitis, were included in the study. The subjects were divided into four groups: group I included eight subjects with chronic gingivitis who had not previously received any ciprofloxacin; group II included eight subjects with chronic gingivitis to whom three doses of ciprofloxacin were administered (Siprosan 500 mg) to establish adequate gingival crevicular fluid and serum concentrations of the agent; group III consisted of eight subjects with chronic periodontitis who had not received any ciprofloxacin; group IV included eight subjects with chronic periodontitis to whom three doses of ciprofloxacin were administered to establish adequate gingival crevicular fluid and serum concentrations of the agent.

Streptococcal gingivitis: a report of case with a description of a unique gingival prosthesis.

Acute streptococcal gingivitis is an acute inflammation of the oral mucosa. Specific bacterial infections of the gingiva may be due to neisseria gonorrhea, treponema pallidum, streptococci, and other organisms. Streptococcal infections are seen rarely.

Abrasion resistance of veneering materials to tooth brushing.

This study was carried out to comparatively examine abrasion which occurred as a result of brushing as well as abrasives in veneering materials used in prosthetic restorations. Twenty out of forty specimens prepared at the dimensions of 14x5x3 mm, there being ten specimens of each veneering materials, were subjected to tooth brushing with water alone. The other twenty specimens were subjected to a tooth brushing procedure with a paste- water mixture with the aim of evaluating the effects of abrasives on abrasion.

Effect of tongue brushing on oral malodor in adolescents.

Background: Halitosis is a common problem in humans, and is a social and psychological handicap for those affected by it. Halitosis has a positive correlation with the accumulation of bacterial plaque in the oral cavity.

Aims: The aim of the present study was to determine the effect of tongue brushing on oral malodor in adolescents.