Publications by authors named "Recep Emrah Cevik"
(HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV infection is the viral nonstructural protein NS5A, which, in addition to its role in replication and assembly, targets several pathways involved in the cellular response to viral infection.
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- The study investigates how iron (Fe) levels affect the replication of the hepatitis C virus (HCV) in liver cells (hepatocytes).
- High levels of Fe, induced by treatment, were found to reduce HCV replication, while reducing hepcidin (a key Fe modulator) increased iron storage and also inhibited HCV replication.
- It was discovered that alpha interferon influences hepcidin at the mRNA level, suggesting that modifying hepcidin could create an environment less favorable for HCV, enhancing our understanding of HCV and liver cell interactions during infection.