Publications by authors named "Rece D Camadine"
Background: Intermittent access to ethanol drives persistent escalation of intake and rapid transition from moderate to compulsive-like drinking. Intermittent ethanol drinking may facilitate escalation of intake in part by altering aversion-sensitive neural substrates, such as the insular cortex (IC), thus driving greater approach toward stimuli previously treated as aversive.
Methods: We conducted a series of experiments in rats to examine behavioral and neural responses associated with escalation of ethanol intake.
Article Synopsis
- Opioid use disorder (OUD) is a serious global public health crisis characterized by compulsive drug-seeking behaviors, often leading to increased risk of overdose and death.
- Research has shown that nicotine use can heighten the likelihood of misusing prescription opioids, with studies in rats demonstrating that nicotine significantly increases the consumption of synthetic opioids like remifentanil, even in situations where punishment is applied.
- The findings suggest that acute nicotine administration makes male rats more motivated to seek opioids and slower to stop that behavior after withdrawal, indicating a strong link between nicotine and the persistence of opioid-seeking behaviors despite negative consequences.