Publications by authors named "Rebekka Wolfensberger"
Introduction: Very little is known about the role of macrophages as immune mediators during natural HIV infection. Humanized mice are an extremely valuable model for studying HIV pathogenesis. However, the presence of murine mononuclear phagocytes in these models represents a significant limitation for studying their human counterpart.
View Article and Find Full Text PDFIn people with HIV-1 (PWH), (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals.
View Article and Find Full Text PDFInfection with Mycobacterium tuberculosis (MTB) remains one of the most important opportunistic infections in people with HIV-1 (PWH). While active Tuberculosis (TB) leads to rapid progression of immunodeficiency in PWH, the interaction between MTB and HIV-1 during the asymptomatic phase of both infections remains poorly understood. In a cohort of individuals with HIV (PWH) with and without suppressed HIV-1 viral load, the transcriptomic profiles of peripheral blood mononuclear cells (PBMC) clustered in individuals infected with Mycobacterium tuberculosis (MTB) compared to carefully matched controls.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the relationship between genomic diversity and the evolution of cooperative systems, such as animal societies and microbial groups, emphasizing the need for better characterization of these systems.
- The researchers analyzed 120 natural isolates of a cooperative bacterium taken from six multicellular fruiting bodies, revealing that each fruiting body was composed of multiple lineages from a single recent ancestor.
- The findings indicate that evolutionary changes in social behavior are driven by genomic evolution in specific hotspots, with kin lineages diverging significantly over generations while still cooperating, suggesting a strong link between genetic variation and social coevolution.
Article Synopsis
- The Irrawaddy dolphin population in the Mekong River is endangered due to low numbers, slow reproduction rates, and human threats, making it crucial to understand the roots of their genetic diversity issues.
- Research showed that most dolphins in the Mekong have a similar genetic makeup and low genetic diversity, indicating long-term isolation from other populations.
- To ensure the survival of the Mekong dolphins, immediate action is needed to minimize human impacts, support population connectivity, and prevent further genetic loss.