Publications by authors named "Rebekka Fendt"
Article Synopsis
- Liver cirrhosis impacts how drugs are metabolized, complicating the study of these changes in drug pharmacokinetics.
- In a study with mice, cirrhosis was induced using carbon tetrachloride, and a mix of six drugs was administered to analyze drug levels in blood, bile, and urine.
- Surprisingly, even with reduced activity of some key enzymes, overall drug clearance remained stable due to compensatory mechanisms, leading to increased levels of glucuronides in the blood.
Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.
CPT Pharmacometrics Syst Pharmacol
July 2021
Physiologically based pharmacokinetic (PBPK) models have been proposed as a tool for more accurate individual pharmacokinetic (PK) predictions and model-informed precision dosing, but their application in clinical practice is still rare. This study systematically assesses the benefit of using individual patient information to improve PK predictions. A PBPK model of caffeine was stepwise personalized by using individual data on (1) demography, (2) physiology, and (3) cytochrome P450 (CYP) 1A2 phenotype of 48 healthy volunteers participating in a single-dose clinical study.
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