Publications by authors named "Rebekah-Louise Scanlan"
Skin ageing is defined, in part, by collagen depletion and fragmentation that leads to a loss of mechanical tension. This is currently believed to reflect, in part, the accumulation of senescent cells. We compared the expression of genes and proteins for components of the extracellular matrix (ECM) as well as their regulators and found that in vitro senescent cells produced more matrix metalloproteinases (MMPs) than proliferating cells from adult and neonatal donors.
View Article and Find Full Text PDFThe DNA repair enzyme, aprataxin, plays a role in innate immune signaling.
Front Aging Neurosci
December 2023
Article Synopsis
- - Ataxia with oculomotor apraxia type 1 (AOA1) is a neurodegenerative disorder that leads to coordination issues in movement, speech, and eye tracking, caused by mutations in the APTX gene which is important for DNA repair.
- - APTX deficiency results in mitochondrial dysfunction and increased DNA damage, which may activate immune responses, leading to inflammation due to misplacement of DNA in the cells.
- - The study found that APTX knockout in microglial cells affects their immune response, with downregulation of key pathways related to DNA and RNA sensing, suggesting the need for further research into potential treatments for AOA1.