Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study.

Background: Hereditary angioedema (HAE) is a potentially life-threatening inherited disease that causes recurrent, serious, and debilitating episodes of swelling. While evidence has improved in adult patients, data on the epidemiology and treatment of pediatric patients with HAE remain very limited. The aim of this study was to determine the incidence and prevalence of pediatric patients with HAE aged <12 years, as well as treatment patterns, co-medication, and specialties involved.

Dosing Patterns of Dulaglutide and Semaglutide in Patients with Type 2 Diabetes in the United Kingdom and Germany: A Retrospective Cohort Study.

Introduction: As new glucagon-like peptide 1 receptor agonist (GLP-1 RA) formulations are available, the aim of this study was to understand dulaglutide and subcutaneous (s.c.) semaglutide dosing patterns in people with type 2 diabetes mellitus (T2DM) in the UK and Germany as well as oral semaglutide in the UK.

Incidence of Newly-Diagnosed Dementia After COVID-19 Infection versus Acute Upper Respiratory Infection: A Retrospective Cohort Study.

Background: There is emerging evidence that coronavirus disease 2019 (COVID-19) is giving rise to seemingly unrelated clinical conditions long after the infection has resolved.

Objective: The aim of this study is to examine whether COVID-19 is associated with an increased risk of dementia including Alzheimer's disease.

Methods: This retrospective cohort study is based on longitudinal data from the IQVIATM Disease Analyzer database and included patients aged≥65 with an initial diagnosis of COVID-19 or acute upper respiratory infection (AURI) from 1,293 general practitioner practices between January 2020 and November 2021.

Association Between Psoriasis and Dementia: A Retrospective Cohort Study.

Background: To date, no large study has examined the relationship between psoriasis and dementia in Germany.

Objective: The aim of this study was to assess the association between psoriasis and the risk of all-cause dementia in patients followed in general practices in Germany.

Methods: This retrospective cohort study is based on longitudinal data from the IQVIA Disease Analyzer database and included patients with an initial diagnosis of psoriasis between January 1995 and December 2014 in 1,173 general practices in Germany.

Uptake of HPV vaccination among boys after the introduction of gender-neutral HPV vaccination in Germany before and during the COVID-19 pandemic.

Background: HPV vaccination has been recommended and reimbursed for girls in Germany since 2007. In June 2018 the German Standing Committee on Vaccination (STIKO) recommended the gender-neutral vaccination of adolescents aged 9 to 14 years with catch-up through age 17. Objectives of this study were to describe the uptake of vaccination in boys before and during the COVID-19 pandemic.

Metabolic syndrome in primary care: A latent variable analysis of electronic medical records.

Background: The best definition of the metabolic syndrome (MetSyn) remains controversial. The aim was to develop a latent variable measurement model for the MetSyn using primary care data.

Methods: This retrospective case-control study was based on the data from the IQVIA Disease Analyzer (DA) database including a representative panel of general and internal medicine practices in Germany.

Investigation of the representativeness of the German IQVIA Vaccine Analyzer database.

Purpose: The aim of this study was to investigate the representativeness of the German IQVIA Vaccine Analyzer (VA) database with respect to vaccination rates in Germany.

Materials And Methods: Descriptive statistics for the demographic characteristics of the patients like gender and age distribution and vaccination rates of various types of vaccinations in children, adolescents, and adults were calculated and compared to official data sources in Germany. The vaccination rates were calculated as the ratio between extrapolated vaccinated patient numbers from the database and official population counts from the Federal Statistical Office.

Association Between Inflammatory Bowel Disease and Dementia: A Retrospective Cohort Study.

Background: The critical role of inflammatory processes in the pathogenesis of dementia has recently been established.

Objective: The aim of this study was to investigate the association between inflammatory bowel disease (IBD) and dementia risk in patients followed in general practices in Germany.

Methods: This study included patients aged over 60 with an initial diagnosis of IBD (Crohn's Disease (CD), ulcerative colitis (UC)) who were followed in 1,159 German general practices between January 1995 and December 2014.

Association Between Low-Density Lipoprotein Cholesterol Levels, Statin Use, and Dementia in Patients followed in German General Practices.

Background: No studies have been conducted to date on the association between low-density lipoprotein cholesterol (LDL-C), statin use classified into low, medium, and high statin dosages, and dementia in German general practices.

Objective: The goal of this retrospective case-control study was to investigate the relationship between elevated LDL-C, statins, and dementia in elderly persons followed in general practices in Germany.

Methods: This study included patients aged 65 or older with an initial dementia diagnosis between January 2015 and December 2019 and at least one documented LDL-C value within the year prior to the dementia diagnosis.