The development of Picture Comprehension Across Early Environments: Evidence From Urban and Rural Toddlers in Western Kenya.

Early childhood researchers frequently use learning materials and assessments involving pictures, across different cultures and contexts. However, there is variation in when and how children across cultures and contexts begin to understand and learn from pictures. While children growing up in high-income contexts often have more experience with picture books and other kinds of two-dimensional visual symbols, children growing up in low-income, rural contexts in low- and middle-income countries often have less experience with pictures and other kinds of visual symbols.

Preschoolers' Comprehension of Functional Metaphors.

Previous work suggests that preschoolers often misunderstand metaphors. However, some recent studies demonstrate that preschoolers can represent abstract relations, suggesting that the cognitive foundations of metaphor comprehension may develop earlier than previously believed. The present experiments used novel paradigms to explore whether preschoolers ( = 200; 4-5 years; 100 males, 100 females; predominantly White) can understand metaphors based on abstract, functional similarities.

Preschoolers and adults metonymically extend proper names to owned objects.

Three preregistered experiments, conducted in 2021, investigated whether English-speaking American preschoolers (N = 120; 4-6 years; 54 females, predominantly White) and adults (N = 80; 18-52 years; 59 females, predominantly Asian) metonymically extend owners' names to owned objects-an extension not typically found in English. In Experiment 1, 5- and 6-year-olds and adults extended names to owned objects over duplicates (d = 0.34 in children; d = 1.

Preschoolers and Adults Learn From Novel Metaphors.

Although adults use metaphors to guide their thinking and reasoning, less is known about whether metaphors might facilitate cognition earlier in development. Previous research shows that preschoolers understand metaphors, but less is known about whether preschoolers can learn from metaphors. The current preregistered experiment investigated whether adults ( = 64) and 3- and 4-year-olds ( = 128) can use metaphors to make new inferences.

An Implementation Evaluation of A Group-Based Parenting Intervention to Promote Early Childhood Development in Rural Kenya.

Early childhood development (ECD) parenting interventions can improve child developmental outcomes in low-resource settings, but information about their implementation lags far behind evidence of their effectiveness, hindering their generalizability. This study presents results from an implementation evaluation of Msingi Bora ("Good Foundation" in Swahili), a group-based responsive stimulation and nutrition education intervention recently tested in a cluster randomized controlled trial across 60 villages in rural western Kenya. Msingi Bora successfully improved child cognitive, receptive language, and socioemotional outcomes, as well as parenting practices.

Defining Early-Onset Colon and Rectal Cancers.

Colorectal cancer (CRC) incidence is rising in the young, yet the age of those affected is not clearly defined. In this study, we identify such cohorts and define clinicopathological features of early-onset colon and rectal cancers. The Surveillance, Epidemiology and End Results Program (SEER) database was queried to compare clinicopathological characteristics of colon and rectal cancers diagnosed during 1973-1995 with those diagnosed during 1995-2014.

Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma.

Background: Adjuvant therapy for gastric adenocarcinoma has shown a survival advantage, though it may be underutilized. The purpose of this study is to examine how infrequently adjuvant therapy is administered with curative intent gastrectomy for node positive gastric cancer and the long-term effects to patients.

Methods: The National Cancer Database was queried from 2006-2013 for patients with node positive gastric adenocarcinoma undergoing a potentially curative gastrectomy.

Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum.

Background: Colon and rectal gastrointestinal stromal tumors (GISTs) are rare and poorly characterized. Because the majority of treatment guidelines for GISTs are extrapolated from tumors of gastric and small bowel origin, our aim was to better characterize the unique clinicopathologic features and prognostic factors of colon and rectal GISTs to guide clinical care.

Methods: The National Cancer Data Base (NCDB) was queried from 2006 to 2013 for cases of GISTs in the stomach, colon, and rectum.

Children's representation of abstract relations in relational/array match-to-sample tasks.

Five experiments compared preschool children's performance to that of adults and of non-human animals on match to sample tasks involving 2-item or 16-item arrays that varied according to their composition of same or different items (Array Match-to-Sample, AMTS). They establish that, like non-human animals in most studies, 3- and 4-year-olds fail 2-item AMTS (the classic relational match to sample task introduced into the literature by Premack, 1983), and that robust success is not observed until age 6. They also establish that 3-year-olds, like non-human animal species, succeed only when they are able to encode stimuli in terms of entropy, a property of an array (namely its internal variability), rather than relations among the individuals in the array (same vs.

Charisma in everyday life: Conceptualization and validation of the General Charisma Inventory.

Although both scholars and lay people are fascinated with charismatic individuals, relatively few theorists have attempted to define charisma. Much of the empirical research examining charisma has focused on leadership. Even within that literature, however, theorists have focused on charisma's outcomes, leaving unarticulated what charisma actually is.

Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer.

Background: Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, accounts for 3% of newly diagnosed cases of colorectal cancer. While a partial or subtotal colectomy is indicated for early stage disease, there is a paucity of data addressing locally advanced disease involving the foregut.

Case Presentation: We report two patients with hereditary nonpolyposis colorectal cancer presenting with locally advanced colon cancer surgically managed by pancreaticoduodenectomy with en bloc partial colectomy and a review of the literature.

Patients with Rheumatoid Arthritis have Similar Excellent Outcomes after Total Knee Replacement Compared with Patients with Osteoarthritis.

Objective: Although new treatments for rheumatoid arthritis (RA) are extremely effective in preventing disease progression, rates of total knee replacement (TKR) continue to rise. The ongoing need for TKR is problematic, especially as functional outcomes in patients with RA have been reported to be worse than in patients with osteoarthritis (OA). The purpose of this study is to assess pain, function, and quality of life 2 years after TKR in contemporary patients with RA compared with patients with OA.

Short-Term Total Hip Arthroplasty Outcomes in Patients With Psoriatic Arthritis or Psoriatic Skin Disease Compared to Patients With Osteoarthritis.

Objective: Outcomes of total hip arthroplasty (THA) in patients with psoriasis have been poorly studied. This study was undertaken to assess whether patients with psoriatic arthritis (PsA) or those with cutaneous psoriasis (PsC) without evidence of inflammatory joint disease are at an increased risk for worse outcomes after THA as compared to patients with osteoarthritis (OA).

Methods: Among subjects in a prospective THA registry, PsA and PsC cases were identified by International Classification of Diseases, Ninth Revision codes, and all cases were matched with patients with OA as controls.

Short-term total hip replacement outcomes in ankylosing spondylitis.

Background: While rates of total hip replacement (THR) in spondyloarthritis are increasing, contemporary outcomes are not well described.

Objectives: This study analyzes 2-year outcomes in a contemporary cohort of ankylosing spondylitis (AS) patients undergoing THR.

Methods: A case-control study was performed using data from an institutional arthroplasty registry.

Patients with rheumatoid arthritis are more likely to have pain and poor function after total hip replacements than patients with osteoarthritis.

Objective: Total hip replacement (THR) outcomes have been worse for patients with rheumatoid arthritis (RA) compared with those who have osteoarthritis (OA). Whether this remains true in contemporary patients with RA with a high use of disease-modifying and biologic therapy is unknown. The purpose of our study is to assess pain, function, and quality of life 2 years after primary THR, comparing patients with RA and patients with OA.

Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells.

Dupuytren's disease, (DD), is a fibroproliferative condition of the palmar fascia in the hand, typically resulting in permanent contracture of one or more fingers. This fibromatosis is similar to scarring and other fibroses in displaying excess collagen secretion and contractile myofibroblast differentiation. In this report we expand on previous data demonstrating that POSTN mRNA, which encodes the extra-cellular matrix protein periostin, is up-regulated in Dupuytren's disease cord tissue relative to phenotypically normal palmar fascia.

Wnt expression is not correlated with beta-catenin dysregulation in Dupuytren's Disease.

Background: Dupuytren's contracture or disease (DD) is a fibro-proliferative disease of the hand that results in finger flexion contractures. Increased cellular beta-catenin levels have been identified as characteristic of this disease. As Wnts are the most widely recognized upstream regulators of cellular beta-catenin accumulation, we have examined Wnt gene expression in surgical specimens and in DD-derived primary cell cultures grown in two-dimensional monolayer culture or in three-dimensional FPCL collagen lattice cultures.