Publications by authors named "Rebecca Yakubov"
Article Synopsis
- - The study validates a new DNA methylation-based predictor for meningiomas that has been enhanced for use with modern methylation arrays and shows improved accuracy over the standard 2021 WHO grading system.
- - It uses data from 1,347 meningioma cases, including prospective cases and an external cohort, demonstrating that both the new and original models effectively predict early postoperative recurrence, especially within specific risk subgroups.
- - The new predictor, which is simpler with fewer features, allows for better clinical decision-making, including the use of adjuvant radiotherapy for high-risk patients, and is available as an easy-to-use tool for improved patient stratification in clinical trials.
Article Synopsis
- The study investigates the role of CDKN2A/B deletions in grade 3 meningiomas by analyzing 1,577 samples from various cohorts, revealing that homozygous deletions occur in only 7.1% of cases but are linked to significantly poorer patient outcomes.
- Heterozygous deletions were less common (2.6%) but similarly associated with negative prognoses, while meningiomas with intact CDKN2A/B showed varying outcomes based on CDKN2A mRNA expression.
- The research highlights a connection between CDKN2A expression, elevated mRNA levels, and aggressive tumor behavior, suggesting that immunohistochemical tests are not reliable for distinguishing between deletion statuses but correlate better
New Technologies in Diagnosis and Prognosis of Melanocytic Lesions.
J Clin Aesthet Dermatol
February 2023
Analysis of morphological characteristics for the diagnosis of melanoma remains a challenge. New technologies for the diagnosis and prognosis of melanocytic lesions have been emerging to ensure earlier and more accurate detection. In this article, we review multiple technologies that improve melanoma diagnostic accuracy such as electrical impedance spectroscopy, pigmented lesion assay, reflectance confocal microscopy, and gene expression profile tests.
View Article and Find Full Text PDFObjective: This study aimed to identify school problems and levels of cognitive activity in youths aged 5-18 years with a concussion during the recovery stages of return to school (RTS).
Study Design: In a prospective cohort, participants completed in-person assessments at three time points: First Visit Post-injury, Symptom Resolution Visit, and Follow-Up Visit. These time points varied based on the participants' recovery progress.
Objective: Congregate living settings supporting individuals with intellectual and developmental disabilities (IDD) have experienced unprecedented challenges during the COVID-19 pandemic. This study aimed to explore the development and utilization of infection control policies in congregate living settings supporting individuals with IDD during the COVID-19 pandemic.
Methods: This qualitative study employed an interpretive description using semi-structured interviews involving administrative personnel from agencies assisting those with IDD residing in Developmental Services congregate living settings in Ontario, Canada.
Currently, several classes of oral therapies for psoriasis are in use, in development, or in investigative stages. Standard non-biologic treatments for psoriasis, such as methotrexate, cyclosporine, and acitretin, have generally unfavorable safety profiles and are not ideal for long-term use. This review will address the safety and efficacy of existing and novel oral therapies for psoriasis that target inflammatory pathways via modulation of phosphodiesterase 4 (PDE4), Janus kinases (JAKs), sphingosine 1-phosphate (S1P), A3 adenosine receptors, and rho-associated kinase 2 (ROCK2), with an emphasis on JAK inhibitors.
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