Researchers have recently argued that the capabilities of Large Language Models (LLMs) can provide new insights into longstanding debates about the role of learning and/or innateness in the development and evolution of human language. Here, we argue on two grounds that LLMs alone tell us very little about human language and cognition in terms of acquisition and evolution. First, any similarities between human language and the output of LLMs are purely functional.
View Article and Find Full Text PDFBackground: Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare, neurodegenerative disorder with no disease-modifying treatments. There is a dearth of information in the literature about the patient and caregiver experience living with DRPLA.
Objectives: This study aimed to (1) understand symptoms experienced by adult- and juvenile-onset DRPLA populations and their impact on daily life and (2) explore patient and caregiver treatment goals and clinical trial participation preferences.
Aim: Fluid loss, dehydration and resultant kidney injury are common when a diverting ileostomy is formed during rectal cancer surgery, the consequences of which are unknown. The aim of this retrospective single-site cohort study is to evaluate the impact of sustained postoperative renal dysfunction after rectal resection on long-term renal impairment and survival.
Method: All patients with rectal adenocarcinoma undergoing resection between January 2003 and March 2017 were included, with follow-up to June 2020.
Maternal infection during pregnancy, leading to maternal immune activation (mIA) and cytokine release, increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. Animal models have provided evidence to support these mechanistic links, with placental inflammatory responses and dysregulation of placental function implicated. This leads to changes in fetal brain cytokine balance and altered epigenetic regulation of key neurodevelopmental pathways.
View Article and Find Full Text PDFExposure to maternal immune activation (MIA) in utero significantly elevates the risk of developing schizophrenia and other neurodevelopmental disorders. To understand the biological mechanisms underlying the link between MIA and increased risk, preclinical animal models have focussed on specific signalling pathways in the brain that mediate symptoms associated with neurodevelopmental disorders such as cognitive dysfunction. Reelin signalling in multiple brain regions is involved in neuronal migration, synaptic plasticity and long-term potentiation, and has been implicated in cognitive deficits.
View Article and Find Full Text PDFExposure to inflammatory stressors during fetal development is a major risk factor for neurodevelopmental disorders (NDDs) in adult offspring. Maternal immune activation (MIA), induced by infection, causes an acute increase in pro-inflammatory cytokines which can increase the risk for NDDs directly by inducing placental and fetal brain inflammation, or indirectly through affecting maternal care behaviours thereby affecting postnatal brain development. Which of these two potential mechanisms dominates in increasing offspring risk for NDDs remains unclear.
View Article and Find Full Text PDFSchizophrenia and other neurodevelopmental disorders often have very heterogeneous symptoms, especially regarding cognition: while some individuals may exhibit deficient cognition, others are relatively unaffected. Studies using developmental animal models often ignore phenotypic heterogeneity in favour of traditional treatment/control comparisons. This may result in resilient or unaffected individuals masking the effects of susceptible individuals if grouped together.
View Article and Find Full Text PDFMaternal infection during pregnancy increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. While the mechanisms remain unclear, dysregulation of placental function is implicated. We hypothesised that maternal infection, leading to maternal immune activation and stimulated cytokine production, alters placental and yolk sac amino acid transport, affecting fetal brain development and thus NDD risk.
View Article and Find Full Text PDFBackground: With the increasing integration of technology into society, it is advisable that researchers explore the effects of repeated digital media exposure on our most vulnerable population-infants. Excessive screen time during infancy has been linked to delays in language, literacy, and self-regulation.
Objective: This study explores the awareness of and adherence to the American Academy of Pediatrics' (AAP) recommendations related to avoiding screen time for infants younger than 2 years and the motivational factors associated with screen time exposure.
Background: Effective antenatal care is fundamental to the promotion of positive maternal and new-born outcomes. International guidance recommends an initial visit in the first trimester of pregnancy, with a minimum of four antenatal visits in total: the optimum schedule being eight antenatal contacts. In low- and middle-income countries, many women do not access antenatal care until later in pregnancy and few have the recommended number of contacts.
View Article and Find Full Text PDFMaternal immune activation (mIA) during pregnancy is hypothesised to disrupt offspring neurodevelopment and predispose offspring to neurodevelopmental disorders such as schizophrenia. Rodent models of mIA have explored possible mechanisms underlying this paradigm and provide a vital tool for preclinical research. However, a comprehensive analysis of the molecular changes that occur in mIA-models is lacking, hindering identification of robust clinical targets.
View Article and Find Full Text PDFAs infants form object representations, the patterns viewed on objects' surfaces may be challenging to decipher because these patterns may be created from the surface reflectance of an object (an object property) or from an external source, such as a cast shadow. We tested 7 ½-month-old infants' use of cues that specify the source of patterns seen on the surfaces of real, 3-dimensional objects to individuate those objects. Results suggest that when forming object representations based on patterns, 7½-month-olds rely heavily on temporal and depth cues to distinguish patterns inherent to the object from other types of patterns.
View Article and Find Full Text PDFBackground: Patient flow, from emergency department admission through to discharge, influences hospital overcrowding. We aimed to improve patient flow by increasing discharge lounge (DL) usage.
Local Problem: Patients need to receive a continuum of nursing care to encourage compliance with follow-up care after discharge from the acute care setting.
Gender socialization influences children at early ages, shaping their developing identities. The toys provided by parents deliver some of the earliest gender-based messages by encouraging children to engage in activities associated with, for example, dolls and trucks. In the current study, we measured the influence of parental socialization by assessing 5- and 12 ½-month-old infants' exposure to dolls and trucks and by experimentally manipulating parents' encouragement to play with these toys.
View Article and Find Full Text PDFThe development of object individuation, a fundamental ability that supports identification and discrimination of objects across discrete encounters, has been examined extensively by researchers. There are significant advancements in infants' ability to individuate objects during the first year-and-a-half. Experimental work has established a timeline of object individuation abilities and revealed some mechanisms underlying this ability, however, the influence of adult assistance during object exploration has not yet been explored.
View Article and Find Full Text PDFAdult observers are sensitive to statistical regularities present in natural images. Developmentally, research has shown that children do not show sensitivity to these natural regularities until approximately 8-10 years of age. This finding is surprising given that even infants gradually encode a range of high-level statistical regularities of their visual environment in the first year of life, We suggest that infants may in fact exhibit sensitivity to natural image statistics under circumstances where images of complex, natural textures, such as a photograph of rocks, are used as experimental stimuli and natural appearance is substantially manipulated.
View Article and Find Full Text PDFInfants' ability to accurately represent and later recognize previously viewed objects, and conversely, to discriminate novel objects from those previously seen improves remarkably over the first two years of life. During this time, infants acquire extensive experience viewing and manipulating objects and these experiences influence their physical reasoning. Here we posited that infants' observations of object feature stability (rigid versus malleable) can influence the use of those features to individuate two successively viewed objects.
View Article and Find Full Text PDFA hierarchical progression in infants' ability to use surface features, such as color, as a basis for object individuation in the first year has been well established (Tremoulet, Leslie, & Hall, 2000; Wilcox, 1999). There is evidence, however, that infants' sensitivity to surface features can be increased through multisensory (i.e.
View Article and Find Full Text PDFThe objective of this study was to determine the effectiveness of daily reminder phone calls on reducing no-show rates in the ambulatory care setting. With the initiation of reminder telephone calls over a 6-month period, the no-show rate dropped by 50% from 8% to 4%. The no-show rate with reminder letters over 3 months was reduced by 29% from 8.
View Article and Find Full Text PDFThere is evidence that 4.5-month-olds do not always use surface pattern to individuate objects but that they can be primed to attend to pattern differences through select experiences. For example, if infants are first shown events in which the pattern of an object predicts its function (dotted containers pound and striped containers pour), they will attend to pattern differences in a subsequent individuation task.
View Article and Find Full Text PDFInfants' ability to represent objects has received significant attention from the developmental research community. With the advent of eye-tracking technology, detailed analysis of infants' looking patterns during object occlusion have revealed much about the nature of infants' representations. The current study continues this research by analyzing infants' looking patterns in a novel manner and by comparing infants' looking at a simple display in which a single three-dimensional (3D) object moves along a continuous trajectory to a more complex display in which two 3D objects undergo trajectories that are interrupted behind an occluder.
View Article and Find Full Text PDFThe ability to individuate objects is one of our most fundamental cognitive capacities. Recent research has revealed that when objects vary in color or luminance alone, infants fail to individuate those objects until 11.5 months.
View Article and Find Full Text PDFInfant Behav Dev
December 2009
Object individuation, the capacity to track the identity of objects when perceptual contact is lost and then regained, is fundamental to human cognition. A great deal of research using the violation-of-expectation method has been conducted to investigate the development of object individuation in infancy. At the same time, there is a growing need for converging methods of study.
View Article and Find Full Text PDFOver the last 20 years neuroscientists have learned a great deal about the ventral and dorsal object processing pathways in the adult brain, yet little is known about the functional development of these pathways. The present research assessed the extent to which different patterns of neural activation, as measured by changes in blood volume and oxygenation, are observed in infant visual and temporal cortex in response to events that involve processing of featural differences or spatiotemporal discontinuities. Infants aged 6.
View Article and Find Full Text PDFEvidence indicating that sex-linked toy preferences exist in two nonhuman primate species support the hypothesis that developmental sex differences such as those observed in children's object preferences are shaped in part by inborn factors. If so, then preferences for sex-linked toys may emerge in children before any self-awareness of gender identity and gender-congruent behavior. In order to test this hypothesis, interest in a doll and a toy truck was measured in 30 infants ranging in age from 3 to 8 months using eye-tracking technology that provides precise indicators of visual attention.
View Article and Find Full Text PDF