Role of supplementary motor area in cervical dystonia and sensory tricks.

Sensory trick is a characteristic feature of cervical dystonia (CD), where a light touch on the area adjacent to the dystonia temporarily improves symptoms. Clinical benefit from sensory tricks can be observed before tactile contact is made or even by imagination. The supplementary motor area (SMA) may dynamically interact with the sensorimotor network and other brain regions during sensory tricks in patients with CD.

Classification of Functional Movement Disorders with Resting-State Functional Magnetic Resonance Imaging.

Functional movement disorder (FMD) is a type of functional neurological disorder characterized by abnormal movements that patients do not perceive as self-generated. Prior imaging studies show a complex pattern of altered activity, linking regions of the brain involved in emotional responses, motor control, and agency. This study aimed to better characterize these relationships by building a classifier using a support vector machine to accurately distinguish between 61 FMD patients and 59 healthy controls using features derived from resting-state functional magnetic resonance imaging.

Longitudinal changes in network homogeneity in presymptomatic C9orf72 mutation carriers.

The risk for carriers of repeat expansion mutations in C9orf72 to develop amyotrophic lateral sclerosis and frontotemporal dementia increases with age. Functional magnetic resonance imaging studies have shown reduced connectivity in symptomatic carriers, but it is not known whether connectivity declines throughout life as an acceleration of the normal aging pattern. In this study, we examined intra-network homogeneity (NeHo) in 5 functional networks in 15 presymptomatic C9+ carriers over an 18-month period and compared to repeated scans in 34 healthy controls and 27 symptomatic C9+ carriers.

Longitudinal changes in resting state networks in early presymptomatic carriers of C9orf72 expansions.

Previous cross-sectional imaging studies found differences in brain structure and in resting state networks between presymptomatic carriers of mutations in C9orf72 (C9+) and healthy controls. We carried out a prospective longitudinal study of clinical and resting state functional imaging in a cohort of 15 presymptomatic C9+ carriers to determine whether differences in resting state connectivity prior to developing symptoms reflect static developmental differences or ongoing low-grade degenerative changes. Presymptomatic C9+ carriers were scanned at baseline with follow-up scanning at 6- and 18-months and compared to a cohort of 14 healthy controls scanned longitudinally.

Augmenting visual analysis in single-case research with hierarchical linear modeling.

The purpose of this article is to demonstrate how hierarchical linear modeling (HLM) can be used to enhance visual analysis of single-case research (SCR) designs. First, the authors demonstrated the use of growth modeling via HLM to augment visual analysis of a sophisticated single-case study. Data were used from a delayed multiple baseline design, across groups of participants, with an embedded changing criterion design in a single-case literacy project for students with moderate intellectual disabilities (MoID).

Effects of error correction during assessment probes on the acquisition of sight words for students with moderate intellectual disabilities.

Simultaneous prompting is an errorless learning strategy designed to reduce the number of errors students make; however, research has shown a disparity in the number of errors students make during instructional versus probe trials. This study directly examined the effects of error correction versus no error correction during probe trials on the effectiveness and efficiency of simultaneous prompting on the acquisition of sight words by three middle school students with moderate intellectual disabilities. A single-case adapted alternating treatments (Sindelar, Rosenberg, & Wilson, 1985) embedded in a multiple baseline across word sets design was employed to examine the effects of error correction during probe trials in order to reduce error rates.

Teaching the reading of connected text through sight-word instruction to students with moderate intellectual disabilities.

Sight-word instruction is the most common method of reading instruction for students with Moderate Intellectual Disabilities reported in the research literature. The purpose of this study was to go beyond instruction of single word units to instruction of multiple-word phrases. This study demonstrated the instruction of reading and comprehending individual words and connected text through the use of simultaneous prompting.

Using simultaneous prompting to teach sounds and blending skills to students with moderate intellectual disabilities.

The purpose of this study was to examine the effects of simultaneous prompting on acquisition of letter-sound correspondences and blending skills of previously taught words for three elementary students with moderate intellectual disabilities, and to measure generalization of those skills to untaught words. The three students were first taught to read five nouns using sight-word instruction. After acquisition of the five words the students were taught letter-sound correspondences and to blend the sounds in order to apply word-analysis skills.