Accumulated and differential effects of life events on cognitive decline in older persons: depending on depression, baseline cognition, or ApoE epsilon4 status?

Objectives: The study examined the accumulated as well as the differential influence of negative life events on cognitive decline in older persons, and whether this association was different for persons with normal and poor cognitive functioning, and for ApoE ε4 carriers and noncarriers.

Methods: We used data from the Longitudinal Aging Study Amsterdam (N = 1,356). Data were analyzed using linear mixed models.