Chirality of New Drug Approvals (2013-2022): Trends and Perspectives.

Many drugs are chiral with their chirality determining their biological interactions, safety, and efficacy. Since the 1980s, there has been a regulatory preference to bring single enantiomer to market. This perspective discusses trends related to chirality that have developed in the past decade (2013-2022) of new drug approvals.

Aqueous Au-Pd colloids catalyze selective CH oxidation to CHOH with O under mild conditions.

The selective oxidation of methane, the primary component of natural gas, remains an important challenge in catalysis. We used colloidal gold-palladium nanoparticles, rather than the same nanoparticles supported on titanium oxide, to oxidize methane to methanol with high selectivity (92%) in aqueous solution at mild temperatures. Then, using isotopically labeled oxygen (O) as an oxidant in the presence of hydrogen peroxide (HO) we demonstrated that the resulting methanol incorporated a substantial fraction (70%) of gas-phase O More oxygenated products were formed than the amount of HO consumed, suggesting that the controlled breakdown of HO activates methane, which subsequently incorporates molecular oxygen through a radical process.