Pharmacological interventions for clozapine-induced hypersalivation.

Background: Clozapine is widely used for people with schizophrenia. Although agranulocytosis, weight gain, and cardiac problems are serious problems associated with its use, hypersalivation, sometimes of a gross and socially unacceptable quantity, is also common (30-80%).

Objectives: To determine the clinical effects of pharmacological interventions for clozapine-induced hypersalivation.