Publications by authors named "Rebecca Sun"
Article Synopsis
- Gastric cancer (GC) is a major cause of cancer deaths in China, and this study focuses on the role of tumor mutational burden (TMB) as a predictive biomarker for immunotherapy in GC.
- The research analyzed 206 GC samples to assess TMB's prognostic value and classified TMB-high patients using mutational signatures, identifying eight molecular subtypes based on genetic alterations.
- Findings revealed that TMB-high GC patients showed better survival rates and an immune-activated phenotype, but patients with high levels of Signature 1 had poorer prognoses, indicating varied metabolic characteristics linked to their cancer profiles.
