F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD).

Background: Graft versus host disease (GvHD) is a frequent complication of allogeneic stem cell transplantation (alloSCT), significantly increasing mortality. Previous imaging studies focused on the assessment of intestinal GvHD with contrast-enhanced MRI/CT or F-FDG-PET imaging alone. The objective of this retrospective study was to elucidate the diagnostic value of a combined F-FDG-PET-MRI protocol in patients with acute intestinal GvHD.

Fluorodeoxyglucose F 18 for the Assessment of Acute Intestinal Graft-versus-Host Disease and Prediction of Response to Immunosuppressive Therapy.

Graft-versus-host disease (GVHD) is a common complication that increases morbidity and mortality after allogeneic stem cell transplantation (allo-SCT). Fluorodeoxyglucose F 18 (F-FDG)-positron emission tomography (PET) imaging has been demonstrated to be highly informative for evaluating and mapping of intestinal GVHD. To corroborate and extend existing findings and to investigate whether glucose metabolism assessed by F-FDG-PET might be an effective diagnostic tool to predict corticosteroid-refractory acute GVHD and overall survival.