Publications by authors named "Rebecca Shin-Yee Wong"
Article Synopsis
- Malaysia has experienced a rise in stem cell therapy applications, but it faces regulatory challenges including unregulated clinics and insufficient legislation.
- Urgent actions such as creating specific laws, enhancing monitoring, and boosting public education are necessary for effective regulation of stem cell therapies.
- A collaborative effort among policymakers, regulatory bodies, and healthcare professionals is essential for improving the guidelines and addressing challenges in Malaysia's stem cell research and therapy landscape.
The regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibility of integration of RNA polymerase or not at this region). Among enzymes that control this process, DNA methyltransferase enzymes (DNMTs), are responsible for DNA demethylation at the CpG islands, particularly at the promoter regions, to regulate transcription.
View Article and Find Full Text PDFAs we progress deeper into the digital age, the robust development and application of advanced artificial intelligence (AI) technology, specifically generative language models like ChatGPT (OpenAI), have potential implications in all sectors including medicine. This viewpoint article aims to present the authors' perspective on the integration of AI models such as ChatGPT in clinical medicine and medical education. The unprecedented capacity of ChatGPT to generate human-like responses, refined through Reinforcement Learning with Human Feedback, could significantly reshape the pedagogical methodologies within medical education.
View Article and Find Full Text PDFArticle Synopsis
- Recent research on Bacillus thuringiensis (Bt) paral spores has identified their potential anticancer effects specifically against leukemic cell lines.
- The study analyzed cell viability, apoptosis, and ultrastructural changes in various leukemic cells, revealing that Bt 18 proteins selectively decreased leukemic cell viability while sparing normal human T lymphocytes.
- Mechanistically, the study found that apoptosis was initiated through cell-cycle arrest and confirmed the involvement of glyceraldehyde 3-phosphate dehydrogenase as a binding protein that may trigger these effects.