Publications by authors named "Rebecca Schnitt"
Article Synopsis
- - Oral squamous cell carcinoma (SCC) is a highly aggressive cancer with a low survival rate, and it can undergo a process called epithelial to mesenchymal transition (EMT), which is linked to its growth and spread.
- - Research showed that the integrin alphavbeta6 and Fyn kinase work together to promote EMT in oral SCC, with changes in serum concentration affecting the behavior of these cells.
- - In low serum conditions (1%), Fyn promotes EMT and cell migration, but in high serum (10%), activating Fyn has the opposite effect, indicating that both Fyn kinase and serum growth factors play crucial roles in modulating EMT in oral SCC.
Aims: In the ischaemia-reperfused heart, transforming growth factor beta (TGFbeta) proteins trigger the differentiation of cardiac fibroblasts (CFs) contributing to fibrosis. Reoxygenation of the heart, in addition to being a trigger for reperfusion injury, induces tissue remodelling by hyperoxia-sensitive signalling processes involving TGFbeta. Here, we sought to characterize the molecular mechanisms responsible for the O(2)-sensitive transcriptional induction of TGFbeta in murine CF and to test the significance of such findings in the infarcted myocardium in vivo using laser capture microdissection.
View Article and Find Full Text PDFThe phenotypic switch of cardiac fibroblasts (CFs) to myofibroblasts is essential for normal and pathological wound healing. Relative hyperoxic challenge during reoxygenation causes myocardial remodeling. Here, we sought to characterize the novel O(2)-sensitive molecular mechanisms responsible for triggering the differentiation of CFs to myofibroblasts.
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