In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice.

The presence of a perforation is known to significantly compromise the outcome of endodontic treatment. One potential use of regenerative endodontic therapy might be the repair of root canal perforations. In addition to nutrients and systemic in situ interactions, the 3 main components believed to be essential for tissue regeneration are stem cells, scaffold, and growth factors.