Carprofen-induced oxidative stress in mitochondria of the colonic mucosa of the dog.

The purpose of the study was to compare the conductance and mannitol permeability of canine colonic mucosa in response to carprofen or 2,4-dinitrophenol (DNP) with or without tempol pretreatment. Ten colonic mucosa sections per dog were mounted in Ussing chambers. Treatments were done in duplicate.

Effects of clenbuterol administration on serum biochemical, histologic, and echocardiographic measurements of muscle injury in exercising horses.

Objective: To determine the effects of clenbuterol, at a dosage of up to 3.2 μg/kg for 14 days, PO, on skeletal and cardiac muscle in healthy horses undergoing treadmill exercise.

Animals: 12 healthy horses from 3 to 10 years old.

Clenbuterol toxicosis in three Quarter Horse racehorses after administration of a compounded product.

Case Description: 3 Quarter Horse racehorses were examined for suspected clenbuterol overdose 12 to 24 hours after administration by mouth of a compounded clenbuterol product.

Clinical Findings: All horses developed sinus tachycardia, muscle tremors, hyperhidrosis, and colic. Abnormalities on serum biochemical analysis included hyperglycemia, azotemia, and high creatine kinase activity.

In vitro effect of carprofen and meloxicam on the conductance and permeability to mannitol and the histologic appearance of the gastric mucosa of dogs.

Objective: To evaluate the effects of carprofen and meloxicam on conductance and permeability to mannitol and on the histologic appearance of sections of canine gastric mucosa.

Sample: Gastric mucosa from 6 mature mixed-breed dogs.

Procedures: Sections of gastric mucosa were mounted in Ussing chambers, and carprofen (40 or 400μg/mL [CAR40 and CAR400, respectively]), meloxicam (8 or 80μg/mL [MEL8 and MEL80, respectively]), or no drug (controls) was added to the bathing solution.

Pathophysiologic effects of phenylbutazone on the right dorsal colon in horses.

Objective: To determine pathophysiologic effects of phenylbutazone on the equine right dorsal colon (RDC).

Animals: 12 healthy adult horses.

Procedures: A controlled crossover observational study was conducted.

Effects of carprofen on the integrity and barrier function of canine colonic mucosa.

Objective: To measure effects of carprofen on conductance and permeability to mannitol and histologic appearance in canine colonic mucosa.

Sample Population: Colonic mucosa from 13 mature mixed-breed dogs. Procedures-Sections of mucosa from the transverse colon and proximal and distal portions of the descending colon were obtained immediately after dogs were euthanized.

Flood injury in horses.

There is no way to prepare for every situation that arises in a disaster. By working closely with other producers and agricultural leaders, however, horse owners can lessen the impact of a disaster on their operation. Preparation and detailed planning are the most important aspects of flood-related injury prevention.

Investigation of the effect of black walnut extract on in vitro ion transport and structure of equine colonic mucosa.

Objective: To examine the secretory response (in the presence and absence of prostaglandin inhibition) in vitro and structural alterations of colonic mucosa in horses after intragastric administration of black walnut extract (BWE).

Animals: 14 adult horses.

Procedure: Seven horses were administered BWE intragastrically and monitored for 11 hours.

Prostaglandin E2 and reactive oxygen metabolite damage in the cecum in a pony model of acute colitis.

The objective of this project was to determine early tissue biochemical events associated with increased colonic secretion during the acute stage of castor-oil-induced colitis by measuring cecal mucosal and submucosal malondialdehyde (MDA) and prostaglandin E2 (PGE2), levels in ponies. Intestinal tissue (inflamed or healthy) samples were obtained from 4 age- and sex-matched Shetland ponies. Biochemical methods were used to determine MDA and PGE2 levels in intestinal tissue samples from inflamed and healthy equine intestine.