Publications by authors named "Rebecca S Fox"
Background: Atherosclerotic renal artery (RA) stenosis contributes to hypertension, renal insufficiency and end stage renal disease, and is independently associated with adverse cardiovascular events. Percutaneous renal intervention is efficacious in treating renovascular hypertension and may be effective in stabilizing or improving renal function, thereby reducing cardiovascular risk. However, high rates of procedural complications have been reported.
View Article and Find Full Text PDFObjectives: The purpose of this study was to assess whether the early discontinuation of eptifibatide infusion in nonemergent percutaneous coronary intervention (PCI) is associated with a higher frequency of periprocedural ischemic myonecrosis.
Background: The recommended regimen for eptifibatide is a double bolus followed by an infusion for 18 h. It is not known whether the infusion can be shortened if the PCI is uncomplicated.
Article Synopsis
- The study evaluated the open-artery hypothesis, testing if late-opening of an infarct-related artery through percutaneous coronary intervention (PCI) plus stenting improves patient outcomes after a heart attack compared to medical therapy alone.
- The results showed that while PCI offered a slight improvement in cardiac function at 4 months, this benefit diminished over time, and there were no significant differences in psychological well-being between the two groups.
- Additionally, medical therapy was found to be significantly less expensive and associated with marginally longer quality-adjusted survival after two years compared to routine PCI.
Background: Reports addressing treatment of in-stent restenosis (ISR) are principally derived from clinical trials.
Objectives: To characterize the spectrum of ISR in an unselected population, and to explore clinical and angiographic factors determining management.
Methods: During a prespecified six-month period before the introduction of drug-eluting stents, consecutive cases of ISR that were identified during clinically driven cardiac catheterization at five hospitals offering all approved treatment modalities for ISR were prospectively registered.
Background: Contrast-induced nephropathy (CIN) after cardiac catheterization is common in patients with preexisting renal dysfunction. Studies of oral acetylcysteine to prevent CIN have produced conflicting results. Intravenous N-acetylcysteine (NAC) has logistic advantages in this setting.
View Article and Find Full Text PDFObjectives: We examined the prevalence and severity of renal artery stenosis (RAS) in patients undergoing cardiac catheterization who were deemed at risk for RAS based on clinical or laboratory criteria for study entry, but who had not previously been suspected of having RAS.
Background: The diagnosis of atherosclerotic RAS remains problematic because its clinical manifestations are nonspecific.
Methods: Consecutive patients undergoing non-emergent cardiac catheterization at a single institution during a 12-month period were evaluated using standardized clinical, laboratory, and angiographic criteria.