Treatment with sofosbuvir attenuates the adverse neurodevelopmental consequences of Zika virus infection in infant rhesus macaques.

Zika virus (ZIKV) infection during infancy in a rhesus macaque (RM) model negatively impacts brain development resulting in long-term behavioral alterations. The current study investigated whether postexposure prophylaxis could alleviate these negative neurodevelopmental consequences. Three RM infants received a 14-day course of sofosbuvir (SOF; 15 mg/kg p.

Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey.

With the ultimate goal of developing a more representative animal model of Alzheimer's disease (AD), two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the gene into rhesus oocytes, followed by fertilization and embryo transfer. The -transgene included the AD-associated Swedish K670N/M671L and Indiana V717F mutations () regulated by the human polyubiquitin-C promoter. Overexpression of was confirmed in lymphocytes and brain tissue.