Publications by authors named "Rebecca Pennock"
Article Synopsis
- - The study investigates how bone marrow mesenchymal stem/stromal cells (MSCs) can maintain bone health and repair through signaling pathways, revealing a new signaling mechanism regulated by epidermal growth factor (EGF).
- - EGF activates β-catenin, a vital part of the Wnt signaling pathway, causing it to move to the nucleus, but does not affect Wnt target gene expression or T cell factor activity in MSCs.
- - Using statistical analysis and RNA sequencing, the researchers found that EGF and β-catenin signaling work together to enhance MSC proliferation by relieving cell cycle pathway suppression from traditional EGF signaling.
Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation of mature cells to a condensed mesenchymal blastema, from which replacement tissues develop. Human somatic cells cannot regenerate in this way and differentiation is considered irreversible under normal developmental conditions.
View Article and Find Full Text PDF