Publications by authors named "Rebecca Norcross"
Article Synopsis
- The ERK1/2 signaling pathway is crucial for embryonic development, with the Shoc2 protein playing a key role in modulating these signals.
- Mutations in the shoc2 gene are linked to Noonan-like syndrome with loose anagen hair (NSLH), which affects tissues derived from the neural crest.
- Research using zebrafish showed that loss of Shoc2 disrupts gene expression related to neural crest development and may cause ECM turnover abnormalities observed in NSLH patients.
The ERK1/2 (also known as MAPK3 and MAPK1, respectively) signaling pathway is critical in organismal development and tissue morphogenesis. Deregulation of this pathway leads to congenital abnormalities with severe developmental dysmorphisms. The core ERK1/2 cascade relies on scaffold proteins, such as Shoc2 to guide and fine-tune its signals.
View Article and Find Full Text PDFThe extracellular signal-related kinase 1 and 2 (ERK1/2) pathway is a highly conserved signaling cascade with numerous essential functions in development. The scaffold protein Shoc2 amplifies the activity of the ERK1/2 pathway and is an essential modulator of a variety of signaling inputs. Germline mutations in Shoc2 are associated with the human developmental disease known as the Noonan-like syndrome with loose anagen hair.
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