Evaluation of rates of virologic suppression in HIV-positive patients with varying numbers of comorbidities.

Purpose: To evaluate the impact of the number of comorbidities on virologic suppression in HIV-positive patients.

Methods: This study included patients 18 years or older who were on antiretroviral therapy (ART) with at least 2 visits to an HIV primary care clinic in the past year. The primary outcome was the percentage of patients with an undetectable viral load (a blood HIV RNA level of <20 copies/mL) among groups of patients with 0, 1 or 2, 3 or 4, and 5 comorbidities, respectively.

Development and Validation of VM-PATHI: Vestibular Migraine Patient Assessment Tool and Handicap Inventory.

Objective: The aim of this article is to develop and validate a disease-specific, patient-reported outcome measure for vestibular migraine.

Setting: Tertiary care vestibular center.

Patients: Adult patients with definite or probable vestibular migraine per Barany Society Criteria.

CGRP and Migraine: The Role of Blocking Calcitonin Gene-Related Peptide Ligand and Receptor in the Management of Migraine.

Migraine is a highly prevalent, complex neurological disorder. The burden of disease and the direct/indirect annual costs are enormous. Thus far, treatment options have been inadequate and mostly based on trial and error, leaving a significant unmet need for effective therapies.

Early implementation of QbD in biopharmaceutical development: a practical example.

In drug development, the "onus" of the low R&D efficiency has been put traditionally onto the drug discovery process (i.e., finding the right target or "binding" functionality).