Publications by Rebecca M O'Malley

Publications by authors named "Rebecca M O'Malley"

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Vasodilating procyanidins derived from grape seeds.

David F Fitzpatrick Bettye Bing David A Maggi Richard C Fleming Rebecca M O'Malley

Ann N Y Acad Sci

May 2002

We have shown in previous work that extracts of grape seeds (GSE) and skins, grape juice, and many red wines exhibit endothelium-dependent relaxing (EDR) activity in vitro. This EDR activity involves endothelial nitric oxide (NO) release and subsequent increase in cyclic GMP levels in the vascular smooth muscle cells. The NO/cyclic GMP pathway is known to be involved in many cardiovascular-protective roles.

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