Publications by authors named "Rebecca Loret De Mola"
Unlabelled: Immune checkpoint inhibition (ICI) is effective for replication-repair-deficient, high-grade gliomas (RRD-HGG). The clinical/biological impact of immune-directed approaches after failing ICI monotherapy is unknown. We performed an international study on 75 patients treated with anti-PD-1; 20 are progression free (median follow-up, 3.
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- * A study involving 45 tumors from 38 patients indicated that immune checkpoint inhibitors (ICIs) can lead to improved survival rates, especially in tumors with ultra-high mutation rates or specific genetic characteristics.
- * The research highlights the importance of mutation burden and microsatellite instability (MS-indels) in predicting ICI treatment responses, showing that even tumors typically classified as non-responsive can benefit from this type of immunotherapy.
Purpose: Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection in these individuals.
Patients And Methods: Data were collected from patients with confirmed CMMRD who were registered in the International Replication Repair Deficiency Consortium.
Article Synopsis
- * The review examines existing research on liquid biopsy specifically in pediatric and adult gliomas, focusing on high-grade cases.
- * Although still in early stages, advancements in detecting liquid biomarkers for pHGG could significantly enhance the development of liquid biopsy techniques in neuro-oncology.
Background: Delirium affects 10% to 30% of patients in pediatric intensive care units (PICU) and is associated with increased length of stay and prolonged late sequela. There are no prospective trials evaluating delirium in the pediatric hematology, oncology, and bone marrow transplant (PHO) population. Hypothesizing that delirium is underrecognized in this population, our study aimed to identify the prevalence of delirium in hospitalized PHO patients and associated risk factors.
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