Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma.

amplification occurs in approximately 20-30% of neuroblastoma patients and correlates with poor prognosis. The transgenic mouse model mimics the development of human high-risk neuroblastoma and provides strong evidence for the oncogenic function of MYCN. In this study, we identified mitotic dysregulation as a hallmark of tumor initiation in the pre-cancerous ganglia from mice that persists through tumor progression.

transmission of using naturally infected koala () semen.

Transmission of Chlamydia pecorum infection has generally been assumed to be via the urogenital route and in an attempt to confirm this we investigated an in vitro method of Chlamydia infection using naturally infected koala semen to inoculate a cell line and attempt to estimate C. pecorum infectious load. A total of 57% of 122 koala semen samples had low C.

Investigation of pathology associated with Chlamydia pecorum infection in the male reproductive tract, and the effect on spermatogenesis and semen quality in the koala (Phascolarctos cinereus).

There is growing evidence that Chlamydia pecorum infection of the male koala reproductive tract causes inflammation and pathology of the urogenital tract. Previous studies have revealed that male koalas exhibiting severe clinical signs of urogenital chlamydial disease had an increased incidence of sperm DNA fragmentation and abnormal sperm morphology, suggestive of chronic exposure to C. pecorum infection and/or inflammation in the testis and epididymis, with residual pathology and lesions disrupting spermatogenesis and maturation of spermatozoa.

Orthographic Knowledge and Clue Word Facilitated Spelling in Children With Developmental Language Disorder.

Purpose This study investigated the orthographic knowledge and how orthographic and phonological information could support children with developmental language disorder (DLD) to make more accurate spelling attempts. Method Children with DLD ( = 37) were matched with chronological age-matched (CAM) children and language age-matched children. These children completed specific and general orthographic knowledge tasks as well as spelling task conditions with either no clue word (pretest), a phonological clue word, or an orthographic clue word.

The effect of Chlamydia infection on koala (Phascolarctos cinereus) semen quality.

Although it is well established that chlamydial disease renders female koalas infertile, there has been limited research on its effects on male koala fertility, specifically sperm quality. This study determined whether chlamydial infection adversely affects semen quality of naturally infected koalas and spermatozoa recovered from Chlamydia negative koalas co-incubated in vitro with C. pecorum elementary bodies (EBs).

EPIDEMIOLOGY OF CHLAMYDIA-INDUCED REPRODUCTIVE DISEASE IN MALE KOALAS () FROM SOUTHEAST QUEENSLAND, AUSTRALIA AS ASSESSED FROM PENILE URETHRAL SWABS AND SEMEN.

Declining population sizes of koalas () in SE Queensland (QLD), Australia can partially be attributed to chlamydiosis, with the majority of epidemiological studies focusing on the prevalence of infection and associated pathology in female koalas, with lesser attention given to males. We aimed to explore the epidemiology of infection in the male urogenital tract from wild (hospitalized and free-ranging) koalas in SE QLD. Although 67% of male koalas were infected with in their urogenital tract and 55% were shedding the organism in their semen, only a third of the males sampled presented with overt signs of urogenital disease.

The Effects of Planning and Handwriting Style on Quantity Measures in Secondary School Children's Writing.

The study aimed to evaluate the proposer, translator, editor, and transcriber process model of writing in the context of secondary school children. Eighty-three children completed written texts under conditions that facilitated the proposer and placed resource demands on the transcriber. It was found that the number of words, lexical richness, and the number of sentences were affected by transcription resource demands, while the number of sentences was increased when the proposer was facilitated.

Chlamydia pecorum Infection in the Male Reproductive System of Koalas ( Phascolarctos cinereus).

Chlamydiosis is the most documented and serious disease of koalas, characterized by ocular, urinary, and reproductive lesions. Since little attention has been paid to the pathological effects of this infection in the male reproductive system, we aimed to determine the incidence and severity of reproductive pathology associated with chlamydial infection in male koalas submitted to koala hospitals in southeast Queensland. The entire reproductive tract from 62 sexually mature male koalas not suitable for rehabilitation was evaluated and 677 tissue samples were collected for histology, immunohistochemistry (IHC), and real-time polymerase chain reaction (qPCR).

Ultrasonographic assessment of the male koala (Phascolarctos cinereus) reproductive tract.

Studies documenting the application of ultrasonography to depict normal and pathological changes in koalas (Phascolarctos cinereus), especially in the male, are scarce. Sixty-two wild koalas were used in this study to define ultrasonographic protocols and features for the assessment of the male koala reproductive tract. Testis, epididymis and spermatic cord were examined using a hockey stick transducer.

Decline causes of Koalas in South East Queensland, Australia: a 17-year retrospective study of mortality and morbidity.

Koala populations are in catastrophic decline in certain eastern Australian regions. Spanning from 1997-2013, a database derived from wildlife hospitals in southeast Queensland with N = 20,250 entries was classified by causes of morbidity and mortality. A total of 11 aetiologies were identified, with chlamydiosis, trauma, and wasting being most common.

The causes and prognoses of different types of fractures in wild koalas submitted to wildlife hospitals.

Fractures are a major problem in wild koalas of great veterinary and conservation importance as their occurrence in different locations of the body might result in varying healing success. The aim of this study was to determine the fracture types (defined by location of the fracture) occurring in wild koalas, temporal patterns, possible causes and risk factors of fracture types, and the prognosis for successfully releasing kolas with healed fracture types into the wild. Data from a total of 2031 wild koalas submitted to wildlife hospitals in South-East Queensland, Australia, over a period of 13 years were analysed.

Delay or deficit? Spelling processes in children with specific language impairment.

Unlabelled: Few studies have explored the phonological, morphological and orthographic spellings skills of children with specific language impairment (SLI) simultaneously. Fifteen children with SLI (mean age=113.07 months, SD=8.

Written language skills in children with specific language impairment.

Background: Young children are often required to carry out writing tasks in an educational context. However, little is known about the patterns of writing skills that children with specific language impairment (CwSLI) have relative to their typically developing peers.

Aims: To assess the written language skills of CwSLI and compare these with typically developing peers.

Perception of size-related formant information in male koalas (Phascolarctos cinereus).

Advances in bioacoustics allow us to study the perceptual and functional relevance of individual acoustic parameters. Here, we use re-synthesised male koala bellows and a habituation-dishabituation paradigm to test the hypothesis that male koalas are sensitive to shifts in formant frequencies corresponding to the natural variation in body size between a large and small adult male. We found that males habituated to bellows, in which the formants had been shifted to simulate a large or small male displayed a significant increase in behavioural response (dishabituation) when they were presented with bellows simulating the alternate size variant.

Comparing phonological skills and spelling abilities in children with reading and language impairments.

Background: Bishop and Snowling (2004) proposed that children with language impairments (LI) and children with reading difficulties (RD) can be considered to be on a (phonological) continuum of risk for reading impairments.

Aims: The first aim of the present study was to address two specific hypotheses about the relationship between RD and LI. The severity hypothesis proposes that LI is a more severe form of RD.

The cognitive foundations of reading and arithmetic skills in 7- to 10-year-olds.

A range of possible predictors of arithmetic and reading were assessed in a large sample (N=162) of children between ages 7 years 5 months and 10 years 4 months. A confirmatory factor analysis of the predictors revealed a good fit to a model consisting of four latent variables (verbal ability, nonverbal ability, search speed, and phonological memory) and two manifest variables (digit comparison and phoneme deletion). A path analysis showed that digit comparison and verbal ability were unique predictors of variations in arithmetic skills, whereas phoneme deletion and verbal ability were unique predictors of variations in reading skills.