Publications by authors named "Rebecca L Kitchener"

Article Synopsis
  • Isovaleric acidemia (IVA) is a metabolic disorder caused by a deficiency of isovaleryl-CoA dehydrogenase, leading to serious gastrointestinal and neurological symptoms that can result in long-term disability or death if not detected early.
  • In a study involving 13 Mexican patients, common symptoms included vomiting, lethargy, and seizures, with mean levels of isovalerylcarnitine significantly above normal in symptomatic patients and newborns.
  • The research revealed a complex genetic background with 14 variants in the IVD gene, showing a long diagnostic delay; thus, raising physician awareness and incorporating newborn screening with molecular analysis is crucial for effective management and early detection of this treatable condition.
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Cyanobacteria are photosynthetic prokaryotes that can fix atmospheric CO and can be engineered to produce industrially important compounds such as alcohols, free fatty acids, alkanes used in next-generation biofuels, and commodity chemicals such as ethylene or farnesene. They can be easily genetically manipulated, have minimal nutrient requirements, and are quite tolerant to abiotic stress making them an appealing alternative to other biofuel-producing microbes which require additional carbon sources and plants which compete with food crops for arable land. Many of the compounds produced in cyanobacteria are toxic as titers increase which can slow growth, reduce production, and decrease overall biomass.

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Formaldehyde has long been used in the chemical inactivation of viral material during vaccine production. Viral inactivation is required so that the vaccine does not infect the patient. Formaldehyde is diluted during the vaccine manufacturing process, but residual quantities of formaldehyde are still present in some current vaccines.

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