Publications by authors named "Rebecca L Kaufman"
Article Synopsis
- BoNT/A4 is significantly less potent than BoNT/A1 due to specific amino acid variations in its heavy chain (HC), impacting its ability to bind to the SV2C receptor.
- Previous research identified that these variations in BoNT/A4 reduce binding efficiency to receptor domains, leading to decreased potency.
- Experimental modifications that introduced certain BoNT/A4 variants into BoNT/A1 or vice versa revealed how these changes can either enhance or diminish the potency of the toxins in different biological contexts, emphasizing species-specific differences in receptor interactions.
