Publications by authors named "Rebecca L Gibeault"
Article Synopsis
- ICP4 is the key transcription activator for herpes simplex virus 1 (HSV-1), but its exact role in regulating gene expression is still not fully understood.
- The study reveals that HSV-1 can interact with and alter nucleosomes (the building blocks of chromatin), and that ICP4 specifically enhances the dynamics of certain histones, especially H3.1, to counteract the virus's silencing mechanisms.
- Findings suggest that by preventing stable silencing of HSV-1 genomes, ICP4 plays a crucial role in activating transcription during viral infection.
