Discovery and Preliminary Structure-Activity Investigation of 3-Substituted-1-imidazol-5-yl-1-indoles with In Vitro Activity towards Methicillin-Resistant .

Antibiotics have been the cornerstone of modern medicine saving lives by virtue of being able to cure infectious diseases and to prevent infections in those who are immune compromised. Their intense use has led to a surging increase in the incidence of antibiotic-resistant bacteria resulting in a desperate need for antibiotics with new mechanisms of action. As part of our search for new antimicrobials we have screened an in-house library of compounds and identified two 3-substituted-1-imidazol-5-yl-1-indoles as weak growth inhibitors (MIC 16 µg/mL) against methicillin-resistant (MRSA).