Publications by authors named "Rebecca J Engberg"
Article Synopsis
- The study investigated how effectively different aerosol delivery systems (aerosol adapter vs. aerosol circuit) deliver bronchodilators through high-flow nasal cannula (HFNC) across neonatal, pediatric, and adult models.
- Inhaled lung doses varied by age group, with adults receiving the highest doses, while neonates showed similar results between systems, but the aerosol circuit was slightly better for older children and adults.
- The findings highlight that current aerosol delivery methods have low lung doses (1-5%) and suggest a need for improved systems to enhance treatment efficacy for patients on HFNC.*
Aerosolized lung surfactant therapy during nasal continuous positive airway pressure (CPAP) support avoids intubation but is highly complex, with reported poor nebulizer efficiency and low pulmonary deposition. The study objective was to evaluate particle size, operational compatibility, and drug delivery efficiency with various nasal CPAP interfaces and gas humidity levels of a synthetic dry powder (DP) surfactant aerosol delivered by a low-flow aerosol chamber (LFAC) inhaler combined with bubble nasal CPAP (bCPAP). A particle impactor characterized DP surfactant aerosol particle size.
View Article and Find Full Text PDFBackground: There is limited evidence supporting an optimum method for removing mucus from the airways of hospitalized infants with bronchiolitis. This study was designed to evaluate short-term physiologic effects between nasal aspiration and nasopharyngeal suctioning in infants.
Methods: Sixteen infants requiring hospitalization for supportive management of bronchiolitis were instrumented with transcutaneously measured partial pressure of carbon dioxide ([Formula: see text]) and [Formula: see text] monitoring.