Publications by authors named "Rebecca Hsieh"
Article Synopsis
- Hypercatecholaminergic conditions can lead to heart failure and cardiac fibrosis, and this study aimed to assess how beta-blockade (specifically with propranolol) impacts heart health under these conditions.
- Rats were infused with epinephrine and norepinephrine to induce heart failure, and treatment with propranolol demonstrated significant improvements in cardiac markers related to fibrosis and apoptosis.
- The findings suggest that propranolol effectively mitigates the harmful effects of excessive catecholamines via the p-38 pathway and helps prevent heart damage by reducing profibrotic changes.
The spatiotemporal organization of membrane-associated molecules is central to the regulation of cellular signals. Powerful new microscopy techniques enable the three-dimensional visualization of localization and activation of these molecules; however, the quantitative interpretation and comparison of molecular organization on the three-dimensional cell surface remains challenging because cells themselves vary greatly in morphology. Here we introduce u-signal3D, a framework to assess the spatial scales of molecular organization at the cell surface in a cell-morphology-invariant manner.
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- Severe hyper-catecholaminergic states can lead to heart failure and cardiac fibrosis, but the effects of beta-blockade in these conditions are not well understood.
- This study examined the impact of various dosages of propranolol on rats experiencing hyper-acute catecholamine-induced heart failure, revealing that low-dose propranolol (1 mg/kg) led to better survival rates compared to higher doses and catecholamine-only groups.
- Findings suggested that catecholamine-induced heart failure activates pre-fibrotic pathways through FGF-23 upregulation, and low-dose propranolol improved cardiac function by reducing FGF-23 levels and enhancing hemodynamic parameters.
Background And Aims: Biliary tract cancer (BTC) is rare and has limited treatment options. We aimed to examine aspirin use on cancer-specific survival in various BTC subtypes, including gallbladder cancer, ampulla of Vater cancer, and cholangiocarcinoma.
Approach And Results: Nationwide prospective cohort of newly diagnosed BTC between 2007 and 2015 were included and followed until December 31, 2017.
Objectives: To assess the prevalence of caries and malocclusion in Mayan Mexican adolescents, 14-20 years of age, living in Chiapas, Mexico.
Methods: This was a cross-sectional, population-based, quantitative, epidemiological study. Sites were chosen to capture subjects representative of the state's Mayan population.
Activation of rabbit TLR9 by different CpG-ODN optimized for mouse and human TLR9.
Comp Immunol Microbiol Infect Dis
September 2012
Synthetic CpG-oligodeoxynucleotides (CpG-ODN) are potent adjuvants that accelerate and boost antigen-specific immune responses. Toll-like receptor 9 (TLR9) is the cellular receptor for these CpG-ODN. Previous studies have shown species-specific activation of mouse TLR9 (mTLR9) and human TLR9 (hTLR9) by their optimized CpG-ODN.
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