Publications by authors named "Rebecca Grossmann"
Molecular HLA typing techniques are currently undergoing a rapid evolution. While real-time PCR is established as the standard method in tissue typing laboratories regarding allocation of solid organs, next generation sequencing (NGS) for high-resolution HLA typing is becoming indispensable but is not yet suitable for deceased donors. By contrast, high-resolution typing is essential for stem cell transplantation and is increasingly required for questions relating to various disease associations.
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- The study explores the role of human leukocyte antigens (HLA) and their haplotypes in predicting outcomes for patients with HPV-driven head and neck squamous cell carcinoma (HNSCC), particularly focusing on oropharyngeal squamous cell carcinoma (OPSCC).
- Results show altered distributions of HLA antigens in HNSCC patients, with certain HLA traits combined with lifestyle factors (like alcohol and tobacco use) significantly influencing progression-free and tumor-specific survival outcomes.
- The research proposes a new risk scoring system that categorizes patients into distinct risk groups, potentially enhancing prognostic capabilities for HPV-driven HNSCC.
Cortical networks are shaped by sensory experience and are most susceptible to modifications during critical periods characterized by enhanced plasticity at the structural and functional level. A system particularly well-studied in this context is the mammalian visual system. Plasticity has been documented for the somatodendritic compartment of neurons in detail.
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