Virtual Simulation to Increase Self-efficacy Through Deliberate Practice.

Background: To reduce performance anxiety and increase engagement in medical-surgical simulations, virtual simulation (VS) was introduced prior to complex high-fidelity simulation to increase students' self-efficacy.

Problem: A presimulation preparation needed to be expanded for high-fidelity simulation involving emergent clinical situations.

Approach: Combined frameworks of Ericsson's theory of deliberate practice and Bandura's self-efficacy theory were applied.

Amyloid-β alters the DNA methylation status of cell-fate genes in an Alzheimer's disease model.

Alzheimer's disease (AD) is characterized by neurofibrillary tangles and extracellular amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding the role of Aβ in the pathogenesis of this neurodegenerative disease. While several studies have focused on the mutations associated with AD, our understanding of the epigenetic contributions to the disease remains less clear.