Publications by authors named "Rebecca Fenwick"
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.
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- A new class of factor Xa inhibitors was developed using a specific chemical structure called 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one, featuring an alanylamide group.
- The compound known as N-2-(morpholin-4-yl)-2-oxoethyl derivative 24 demonstrated strong effectiveness as a selective inhibitor of factor Xa, which is important for blood clotting.
- Additionally, this compound showed promising results in terms of how well it is absorbed and utilized in the body for both rats and dogs, indicating good potential for oral medication.