is required for cardiovascular development and interacts with in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis.

Developmental defects affecting the heart and aortic arch arteries are a significant phenotype observed in individuals with 22q11 deletion syndrome and are caused by a microdeletion on chromosome 22q11. , one of the deleted genes, is expressed throughout the pharyngeal arches and is considered a key gene, when mutated, for the arch artery defects. is expressed in the pharyngeal endoderm and is downregulated in mutant mice.

Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system.

The neurotransmitter serotonin (5-HT) is involved in mood disorder aetiology and it has been reported that (organophosphate) OP exposure affects 5-HT turnover. The aim of this study was to elucidate the mechanism underlying OP effects on the adult 5-HT system. First, acute in vivo administration of the OP diazinon (0, 1.

Attempted ignition of petrol vapour by lit cigarettes and lit cannabis resin joints.

A recent murder enquiry prompted experimentation to confirm and visually demonstrate that lit cigarettes are not a viable source of ignition of petrol vapour. In addition, tests comprising the attempted ignition of petrol vapour using hot and smouldering cannabis resin were also undertaken. A series of experiments was also designed to recreate circumstances specific to the crime under investigation by undertaking cigarette/joint ignition tests involving a mannequin clothed in a cotton garment onto which petrol was applied.

The role of graded category structure in imaginative thought.

Participants generated lists of exemplars from the categories of animals, tools, and fruit, and their lists were used to determine the relative accessibility of individual exemplars. Measures of accessibility included output dominance (the number of participants who listed an exemplar), rank (how early instances were listed), and two scores that reflect their combination-output precedence and dominance/rank. Other participants drew and described novel exemplars of those categories that might exist on an imaginary planet and reported on the factors that influenced their creations.