Publications by authors named "Rebecca D Bair"
Article Synopsis
- Scientists studied a group of people with multiple sclerosis (MS) to find a special antibody that could help diagnose the disease.
- They found that about 10% of these patients had a unique pattern of antibodies that could appear years before they showed any symptoms of MS.
- This discovery might help doctors identify people at high risk for MS earlier, even before the disease fully develops.
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster of PwMS that share an autoantibody signature against a common motif that has similarity with many human pathogens.
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