Publications by authors named "Rebecca Collier"
Assisted Reproductive Technologies (ART) have revolutionized infertility treatment and animal breeding, but their success largely depends on selecting high-quality oocytes for fertilization and embryos for transfer. During preimplantation development, embryos undergo complex morphogenetic processes, such as compaction and cavitation, driven by cellular forces dependent on cytoskeletal dynamics and cell-cell interactions. These processes are pivotal in dictating an embryo's capacity to implant and progress to full-term development.
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- Lynch syndrome is a hereditary cancer syndrome linked to mutations in mismatch repair genes, increasing the risk for various cancers, especially colorectal and endometrial cancer, and recently identified as a risk factor for early-onset aggressive prostate cancer.
- The IMPACT study, an international research project, is evaluating the effectiveness of prostate-specific antigen (PSA) screening among men aged 40-69 with and without these genetic variants to determine the incidence and characteristics of prostate cancer.
- Initial findings from the first round of PSA screenings indicate differences in prostate cancer detection and characteristics between men with pathogenic variants compared to age-matched controls who do not carry these variants.
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- The study investigates the role of p38-MAPK in mouse preimplantation development, focusing on how it affects the differentiation of the inner cell mass (ICM) and primitive endoderm (PrE) by regulating RNA processing and translation.
- Researchers specifically examine DEAD-box RNA helicase 21 (DDX21), finding that its expression is crucial during blastocyst development and is associated with p38-MAPK activity.
- Results from knockdown experiments reveal that reduced DDX21 leads to significant defects in cell proliferation and differentiation, highlighting its importance in lineage-specific translation regulation in the early stages of mouse embryo development.
The purpose of this study was to determine the effect of adiposity on the architecture and composition of hip OA subchondral bone, and to examine the pathological role of adipokines. Femoral heads were collected from normal-weight or over-weight/obese patients with hip OA. Structural parameters of subchondral bone were determined by MicroCT and type I collagen α1/α2 ratio was determined by SDS PAGE and by qRT-PCR in ex-vivo bone explants.
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