Publications by authors named "Rebecca Chornock"
Obstetrical and neonatal outcomes in patients with surgically repaired heart disease.
Am J Obstet Gynecol MFM
April 2024
Background: Congenital and acquired heart disease complicate 1% to 4% of pregnancies in the United States. Beyond the risks of the underlying maternal congenital heart disease, cardiac surgery and its sequelae, such as surgical scarring resulting in higher rates of arrhythmias and implanted valves altering anticoagulation status, have potential implications that could affect gestation and delivery.
Objective: This study aimed to investigate whether history of maternal cardiac surgery is associated with adverse obstetrical or neonatal outcomes compared with patients without a history of cardiac disease or surgery, considered "healthy controls.
Article Synopsis
- Preterm premature rupture of membranes is when a pregnant woman’s water breaks too early, and it's a common cause of early deliveries.
- Doctors often give antibiotics to help improve the chances of the baby staying in the womb longer, and azithromycin is a new option being studied.
- This study looked at whether taking azithromycin for a longer time helps extend the time before the baby is born and also checked for any health problems in babies after birth.
Objective: This study aimed to evaluate term neonatal outcomes after maternal magnesium sulfate (MgSO) treatment for seizure prophylaxis.
Study Design: This was a single-site retrospective cohort study of all women with term singleton gestation requiring MgSO treatment for seizure prophylaxis and their respective neonatal outcomes from January 2013 through December 2020. Our primary outcome was neonatal intensive care unit (NICU) admission.
Article Synopsis
- This study aimed to determine if women with a history of open cardiac surgery and preexisting cardiac arrhythmias face worse obstetrical outcomes.
- It compared the outcomes of 69 deliveries from women with and without arrhythmias after their surgeries, looking at both maternal and neonatal health indicators.
- The findings indicated that women with arrhythmias were more likely to experience severe preeclampsia and have low birth weight babies compared to those without arrhythmias.
Objective: The study aimed to examine the incidence of hypertensive disorders of pregnancy in women diagnosed with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2, also known as COVID-19).
Study Design: This was a retrospective cohort study of all women who delivered at MedStar Washington Hospital Center in Washington, DC from April 8, 2020 to July 31, 2020. Starting April 8, 2020, universal testing for COVID-19 infection was initiated for all women admitted to labor and delivery.
Background: The host adaptive immune response helps determine which cervical HPV infections persist and progress to precancer and cancer, and systematic characterisation of T-cell infiltration would help inform key steps in cervical carcinogenesis.
Methods: A systematic review and meta-analysis were conducted of infiltrating T-cells in normal cervix, low-grade lesions, high-grade lesions, and invasive cancers including epithelial, stromal, and total tissue and the following markers: CD3, CD4, CD8, FoxP3, CD25, and the CD4:CD8 ratio. An additional qualitative review summarised longitudinal data on associations between infiltrating T-cells and cervical disease persistence, regression, progression, or prognosis.
Objective: Postpartum hypertension is a leading cause of readmission in the postpartum period. We aimed to examine the prevalence of racial/ethnic differences in postpartum readmission due to hypertension in women with antepartum pregnancy-associated hypertension.
Study Design: This was a multi-institutional retrospective cohort study of all women with antepartum pregnancy-associated hypertension diagnosed prior to initial discharge from January 2009 to December 2016.
Objective: To evaluate the ability of estimated blood loss (EBL) and quantitative blood loss (qBL) to predict need for blood transfusion in women with postpartum hemorrhage (PPH).
Study Design: This is a retrospective chart review that identified women with PPH (>1,000 mL for vaginal or cesarean delivery) between September 2014 and August 2015, reported by EBL ( = 92), and October 2015 and September 2016, reported by qBL ( = 374). The primary metric was the area under the receiver-operating characteristic curve for blood transfusion.