Publications by authors named "Rebecca C Soslowsky"
Article Synopsis
- Extracellular vesicles (EVs) are tiny packages released by cells like neurons that can carry signals and help with diseases.
- Researchers found that a special machinery called ESCRT helps in releasing these packages, but even without it, some signals from the packages still work.
- The study suggests that EVs might mainly help clean up unwanted materials in the brain rather than just sending signals between cells.
Extracellular vesicles (EVs) are released by many cell types including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular signaling or serve primarily to dispose of unwanted materials. We show that loss of multivesicular endosome-generating ESCRT (endosomal sorting complex required for transport) machinery disrupts release of EV cargoes from motor neurons.
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