Publications by authors named "Rebecca Boyer"
Female carriers of a Duchenne muscular dystrophy (DMD) gene mutation manifest exercise intolerance and metabolic anomalies that may be exacerbated following menopause due to the loss of estrogen, a known regulator of skeletal muscle function and metabolism. Here, we studied the impact of estrogen depletion (via ovariectomy) on exercise tolerance and muscle mitochondrial metabolism in female mdx mice and the potential of estrogen replacement therapy (using estradiol) to protect against functional and metabolic perturbations. We also investigated the effect of estrogen depletion, and replacement, on the skeletal muscle proteome through an untargeted proteomic approach with TMT-labelling.
View Article and Find Full Text PDFIntroduction And Hypothesis: Despite the lack of evidence, antibiotic prophylaxis has been recommended for midurethral sling procedures. The goal of this study was to evaluate the rate of infectious complications in women undergoing midurethral sling procedures without antibiotic prophylaxis.
Methods: We reviewed the baseline characteristics and postoperative infectious complications of 174 consecutive women who underwent midurethral sling procedures without prophylactic antibiotics from April 2005 to January 2010.
Introduction And Hypothesis: The objective of this study was to determine if prophylactic antibiotic use before midurethral sling procedures reduces infectious complications.
Methods: In this double-blinded randomized trial, we compared infectious complications between women who received cefazolin and placebo before midurethral sling procedures.
Results: The study was halted due to low rate of infectious outcomes seen at the first scheduled interim analysis.