Publications by authors named "Rebecca B Nadler"
J Clin Invest
September 2024
Article Synopsis
- - The study investigates T cell responses to KRAS mutations, particularly the KRASG12V variant, and focuses on T cell receptors (TCRs) that are specific to this mutation within certain HLA class I alleles.
- - It reports on a clinical vaccine trial that successfully primed both CD8+ and CD4+ T cell responses against KRASG12V, revealing that natural TCRs showed high specificity and effectiveness in targeting mutated cancer cells without affecting normal cells.
- - The findings suggest a strong therapeutic potential for these KRASG12V-specific TCRs in developing targeted T cell therapies, highlighting their ability to effectively attack tumors even with low levels of antigen presentation.
