Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI.

Purpose: To determine which MR technique was the most sensitive to age-related white matter damage. We compared both diffusion tensor imaging (DTI) and magnetization transfer (MT) maps to determine which technique correlated most strongly with cognitive function in a middle-aged and elderly community population.

Materials And Methods: In all, 64 healthy subjects (aged 50-90) underwent MRI and neuropsychology.