Publications by authors named "Rebecca A Kaye"
Purpose: To analyze the choroidal parameters of patients with chronic central serous chorioretinopathy (cCSC) and the association with central serous chorioretinopathy susceptibility genes.
Methods: The choroidal vascular index (CVI) was obtained by binarizing spectral domain optical coherence tomography enhanced depth images of patients with cCSC and healthy age-matched controls. Patients with cCSC were genotyped for three central serous chorioretinopathy susceptibility single-nucleotide polymorphisms: rs4844392 ( mir-29b-2/CD46 ), rs1329428 ( CFH ), and rs2379120 (upstream GATA5 ).
Article Synopsis
- The study investigates how genetic variants linked to age-related macular degeneration (AMD) affect retinal thickness in a healthy population.
- Participants from the UK Biobank had their retinal layers analyzed using advanced imaging techniques.
- The research found that specific genetic markers significantly influenced the thickness of outer retinal layers, particularly indicating changes even in those without visible AMD symptoms.