Publications by authors named "Rebecca A Bekker"

Article Synopsis
  • Tumors interact with the immune system, creating different environments that can affect how well treatments like radiation or immunotherapy work.
  • Inflamed tumors tend to respond better to treatments, while "immune deserts" do not.
  • Researchers are using computer models to study how different radiation methods might help create a better immune response to fight tumors effectively.
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Immunotherapies are a major breakthrough in oncology, yielding unprecedented response rates for some cancers. Especially in combination with conventional treatments or targeted agents, immunotherapeutics offer invaluable tools to improve outcomes for many patients. However, why not all patients have a favorable response remains unclear.

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Radiotherapy is a primary therapeutic modality widely utilized with curative intent. Traditionally tumor response was hypothesized to be due to high levels of cell death induced by irreparable DNA damage. However, the immunomodulatory aspect of radiation is now widely accepted.

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